Gene interactions and pathways from curated databases and text-mining

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PTPN11 — TNF

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: Complex of KDR-PTPN11 → TNF (increases)
    Evidence: TNF- inhibits VEGF signaling by recruiting SHP-2 to the VEGFR2 in ECs (42).

Text-mined interactions from Literome

Fu et al., J Virol 2002 : Regulation of tumor necrosis factor alpha promoter by human parvovirus B19 NS1 through activation of AP-1 and AP-2 ... The molecular mechanisms of NS1 mediated TNF-alpha expression would explain the pathogenesis of B19 associated inflammation
Bode et al., J Immunol 2003 : Since recruitment of the tyrosine phosphatase Src homology protein tyrosine phosphatase 2 ( SHP2 ) to the signal transducing receptor subunit gp130 attenuates IL-6 mediated STAT-activation, we were interested in whether TNF-alpha also induces the association of SHP2 to the gp130 receptor subunit ... In this study we demonstrate that stimulation of macrophages and fibroblast cell lines with TNF-alpha causes the recruitment of SHP2 to the gp130 signal transducing subunit and leads to tyrosine phosphorylation of SHP2 and gp130
Lerner-Marmarosh et al., Arterioscler Thromb Vasc Biol 2003 (Inflammation) : TNF-alpha mediated JNK, c-Jun, and NF-kappaB activation required Src and SHP-2 activity
Ahmed et al., Am J Physiol Gastrointest Liver Physiol 2006 : SHP-1 and SHP-2 protein levels were unaltered by TNF or GH, and the GH-induced increase in SHP-1 PTP activity was not further increased by TNF
Yu et al., J Biol Chem 2009 : SHP2 associated with ASK1 in response to tumor necrosis factor in EC