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PTPN11 — TNF
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
Complex of KDR-PTPN11
→
TNF
(increases)
Evidence: TNF- inhibits VEGF signaling by recruiting SHP-2 to the VEGFR2 in ECs (42).
Text-mined interactions from Literome
Fu et al., J Virol 2002
:
Regulation of
tumor necrosis factor alpha promoter by human parvovirus B19
NS1 through activation of AP-1 and AP-2 ... The molecular mechanisms of
NS1 mediated
TNF-alpha expression would explain the pathogenesis of B19 associated inflammation
Bode et al., J Immunol 2003
:
Since recruitment of the tyrosine phosphatase Src homology protein tyrosine phosphatase 2 ( SHP2 ) to the signal transducing receptor subunit gp130 attenuates IL-6 mediated STAT-activation, we were interested in whether
TNF-alpha also
induces the association of
SHP2 to the gp130 receptor subunit ... In this study we demonstrate that stimulation of macrophages and fibroblast cell lines with
TNF-alpha causes the recruitment of SHP2 to the gp130 signal transducing subunit and
leads to tyrosine phosphorylation of
SHP2 and gp130
Lerner-Marmarosh et al., Arterioscler Thromb Vasc Biol 2003
(Inflammation) :
TNF-alpha mediated JNK, c-Jun, and NF-kappaB activation
required Src and
SHP-2 activity
Ahmed et al., Am J Physiol Gastrointest Liver Physiol 2006
:
SHP-1 and
SHP-2 protein levels were unaltered by TNF or GH, and the GH-induced increase in SHP-1 PTP activity was not further
increased by
TNF
Yu et al., J Biol Chem 2009
:
SHP2 associated with ASK1 in
response to
tumor necrosis factor in EC