We have a suspicion that you are an automated web bot software, not a real user. To keep our site fast for other users, we have slowed down this page. The slowdown will gradually disappear. If you think this is a mistake, please contact us at genome-www@soe.ucsc.edu. Also note that all data for hgGeneGraph can be obtained through our public MySQL server and all our software source code is available and can be installed locally onto your own computer. If you are unsure how to use these resources, do not hesitate to contact us.
UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

◀ Back to MTOR


Text-mined interactions from Literome

Li et al., Toxicol Lett 2012 (MAP Kinase Signaling System) : Interestingly, taurine induced decreasing expression of LC3-II was partially blocked by pretreatment of RAD001 , an mTOR inhibitor
Pantaleo et al., J Exp Clin Cancer Res 2010 (Gastrointestinal Stromal Tumors) : Imatinib and nilotinib directly inhibit the kinase activity of KIT, while RAD001 ( everolimus ) inhibits mTOR
Albert et al., Mol Cancer Ther 2006 (Breast Neoplasms) : Irradiation induced Akt and mTOR signaling , and this signaling is attenuated by RAD001
Moriceau et al., Cancer Res 2010 (Bone Neoplasms...) : In this study, we investigated in vivo the effects of RAD001 ( Everolimus ), a new orally available mTOR inhibitor , on the growth of human and mouse osteosarcoma cells either alone or in combination with zoledronate ( ZOL ), an anti-osteoporotic drug used to treat bone metastases
Parikh et al., Leukemia & lymphoma 2010 (Diarrhea...) : Experience with everolimus ( RAD001 ), an oral mammalian target of rapamycin inhibitor , in patients with systemic mastocytosis ... We tested the efficacy of everolimus ( RAD001 ), a novel oral mTOR inhibitor , at a dose of 10 mg daily in an open label, non-comparative Phase II trial for patients with SM. Ten patients were enrolled from April 2007 to October 2008
Mabuchi et al., Cancer Res 2007 (Disease Models, Animal...) : In vivo effects of RAD001 on Akt-mTOR signaling , tumor cell proliferation, and blood vessel area were analyzed by immunohistochemistry and Western blot analysis
Meikle et al., J Neurosci 2008 (Disease Models, Animal...) : We have tested rapamycin and RAD001 [ 40-O- ( 2-hydroxyethyl ) -rapamycin ], both mammalian target of rapamycin mTORC1 inhibitors , as potential therapeutic agents in this model ... We have tested rapamycin and RAD001 [ 40-O- ( 2-hydroxyethyl ) -rapamycin ], both mammalian target of rapamycin mTORC1 inhibitors , as potential therapeutic agents in this model
Nassim et al., PloS one 2013 (Urinary Bladder Neoplasms) : Clonogenic assays were performed using 6 bladder cancer cell lines ( UM-UC3, UM-UC5, UM-UC6, KU7, 253J-BV, and 253-JP ) in order to examine the effects of ionizing radiation ( IR ) alone and in combination with RAD001 , an mTOR inhibitor
Zatelli et al., Endocr Relat Cancer 2010 (Bronchial Neoplasms...) : It has been previously demonstrated that everolimus, or RAD001 , an mTOR inhibitor , has potent antiproliferative effects in human endocrine tumors
Loehberg et al., Biochem Pharmacol 2012 (Breast Neoplasms...) : Chloroquine and RAD001 inhibited phosphorylation of mTOR and its downstream target, S6K1
Lee et al., Mol Cancer Ther 2011 (Disease Models, Animal...) : Pituitary adenomas show activation of the PI3K/AKT/mTOR pathway, but only a fraction of them respond in vitro to the antiproliferative action of rapamycin and RAD001 ( mTOR inhibitors ), possibly because of the described negative feedback loop on AKT which reactivates the signaling cascade
Józwiak et al., Future Oncol 2012 (Astrocytoma...) : Everolimus ( RAD001 ), a mTOR inhibitor , was initially used as an immunosuppressant in organ transplant patients ; however, it also has significant antineoplastic properties
Mancini et al., J Cell Biochem 2010 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : RAD 001 ( everolimus ) prevents mTOR and Akt late re-activation in response to imatinib in chronic myeloid leukemia
Tam et al., Cancer Lett 2009 (Carcinoma, Hepatocellular...) : In vitro, HCC cell lines were exposed to RAD001 , an mTOR inhibitor , either alone or in combination with cisplatin
Kim et al., Autophagy 2008 (Disease Models, Animal...) : To test this hypothesis, combinations of Z-DEVD ( caspase-3 inhibitor ), RAD001 ( mTOR inhibitor ) and irradiation were tested in cell and mouse models
Park et al., Leukemia 2013 (Leukemia, Myeloid, Acute...) : We conducted a phase Ib trial combining RAD001 ( everolimus ), an allosteric inhibitor of mTORC1 , and conventional chemotherapy, in AML patients under 65 years of age at first relapse ( clinical trial NCT 01074086 )
Nishioka et al., Int J Cancer 2009 (Leukemia, Myeloid, Acute) : Our study explored the drug interaction of all-trans retinoic acid ( ATRA ) and RAD001 ( everolimus ), the inhibitor of mammalian target of rapamycin complex 1 ( mTORC1 ), in acute myelogenous leukemia ( AML ) NB4 and HL60 cells
Fujishita et al., Cell cycle (Georgetown, Tex.) 2009 (Adenoma...) : We have recently found that the mTORC1 pathway is activated in intestinal adenomas of Apc mutant mice, accompanied by an elevated level of mTOR protein, and that treatment with RAD001 , an mTORC1 inhibitor , suppresses the growth of these polyps
Wolpin et al., J Clin Oncol 2009 (Pancreatic Neoplasms) : We performed a multi-institutional, single-arm, phase II study of RAD001 ( everolimus ), an oral inhibitor of mTOR , in patients who experienced treatment failure on first-line therapy with gemcitabine
Haritunians et al., Leukemia 2007 (Lymphoma, Mantle-Cell) : As improved therapy for MCL is required and the mTOR pathway may be involved in its pathophysiology, the antiproliferative effects of RAD001 ( everolimus ), an mTOR inhibitor , against three MCL cell lines were investigated
Rossi et al., Proc Natl Acad Sci U S A 2006 (Disease Models, Animal...) : Treatment with RAD001 ( everolimus ), an mTOR inhibitor , diminished the translational response and cell proliferation in tumor lesions, pointing to mTOR inhibition as a therapeutic approach for imatinib-resistant GIST
Boulay et al., Clin Cancer Res 2005 (Breast Neoplasms...) : RAD001 ( everolimus ), a mammalian target of rapamycin (mTOR) pathway inhibitor in phase II clinical trials in oncology, exerts potent antiproliferative/antitumor activities
Yao et al., J Clin Oncol 2010 (Neuroendocrine Tumors...) : Everolimus ( RAD001 ), an oral inhibitor of mammalian target of rapamycin , in combination with octreotide has demonstrated encouraging antitumor activity in patients with NETs
Schnell et al., Cancer Res 2008 (Mammary Neoplasms, Experimental...) : Because RAD001 , a specific mTOR allosteric inhibitor , was ineffective in the preceding experiments, we concluded that the effects observed for NVP-BEZ235 are in part driven by PI3K target modulation
Xie et al., Int Immunol 2007 (Autoimmune Diseases...) : In addition, blocking this axis using RAD001 , an mTOR inhibitor , ameliorated lymphoproliferation and modulated serum IgG anti-nuclear auto-antibodies
Breuleux et al., Mol Cancer Ther 2009 (Neoplasms) : RAD001 ( everolimus ), an mTORC1 ( mTOR/raptor ) inhibitor , has broad antitumor activity in preclinical models and cancer patients
Rosich et al., Clin Cancer Res 2012 (Lymphoma, Mantle-Cell) : The first clinical studies of everolimus ( RAD001 ), an mTOR inhibitor , in relapsed MCL patients have reported a significant response