Gene interactions and pathways from curated databases and text-mining

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AKT3 — RAPGEF3

Text-mined interactions from Literome

Misra et al., Cell Signal 2008 (MAP Kinase Signaling System) : The cAMP activated GTP exchange factor, Epac1 upregulates plasma membrane and nuclear Akt kinase activities in 8-CPT-2-O-Me-cAMP stimulated macrophages : Gene silencing of the cAMP activated GTP exchange Epac1 prevents 8-CPT-2-O-Me-cAMP activation of Akt activity in macrophages ... In conclusion, we show that cAMP induced Akt kinase activation and cellular proliferation is mediated by Epac1 which appears to function as an accessory protein for Akt activation
Misra et al., PloS one 2013 (Prostatic Neoplasms) : Pretreatment of cells with the COX-2 inhibitor SC-58125 or the EP4 antagonist AH-23848, or with an inhibitor of mTORC1 and mTORC2, Torin1, significantly reduced the Epac1 dependent increase of p-cPLA2 and COX-2, p-S6-kinase ( T389 ), and p-AKT ( S473 )