Gene interactions and pathways from curated databases and text-mining

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PRKAG2 — RETN

Text-mined interactions from Literome

Palanivel et al., FEBS Lett 2005 : Decreased AMPK and ACC phosphorylation were observed in response to resistin while expression of ACC and AMPK isoforms was unaltered
Li et al., Endocrine 2009 (Glucose Intolerance...) : Resistin may inhibit hepatic AMPK activity, which results in elevated expression of gluconeogenic enzymes thereby affecting glucose metabolism and leading to decreased glycogen storage that contributes to the development of hepatic IR
Jørgensen et al., Am J Physiol Endocrinol Metab 2009 : To further investigate the site ( s ) at which resistin impairs glucose uptake we treated myotubes and skeletal muscle with the AMPK activator 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside ( AICAR ) and found that, although resistin did not impair AMPK activation, it reduced AICAR stimulated glucose uptake ... We conclude that resistin impairs insulin stimulated glucose uptake by mechanisms involving reduced plasma membrane GLUT4 translocation but independent of the proximal insulin signaling cascade, AMPK , and SOCS-3