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PRKAG2 — RETN
Text-mined interactions from Literome
Palanivel et al., FEBS Lett 2005
:
Decreased
AMPK and ACC phosphorylation were observed in
response to
resistin while expression of ACC and AMPK isoforms was unaltered
Li et al., Endocrine 2009
(Glucose Intolerance...) :
Resistin may
inhibit hepatic
AMPK activity, which results in elevated expression of gluconeogenic enzymes thereby affecting glucose metabolism and leading to decreased glycogen storage that contributes to the development of hepatic IR
Jørgensen et al., Am J Physiol Endocrinol Metab 2009
:
To further investigate the site ( s ) at which resistin impairs glucose uptake we treated myotubes and skeletal muscle with the AMPK activator 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside ( AICAR ) and found that, although
resistin did not
impair AMPK activation, it reduced AICAR stimulated glucose uptake ... We conclude that
resistin impairs insulin stimulated glucose uptake by mechanisms involving reduced plasma membrane GLUT4 translocation but
independent of the proximal insulin signaling cascade,
AMPK , and SOCS-3