Gene interactions and pathways from curated databases and text-mining

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BCL2 — SALL4

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: BCL2 → SALL4 (increases) Yang et al., Blood 2008*
    Evidence: These genes include 38 important apoptosis- inducing genes (TNF, TP53, PTEN, CARD9, CARD11, CYCS, LTA) and apoptosis-inhibiting genes (Bmi-1, BCL2, XIAP, DAD1, TEGT). Real-time PCR has shown that expression levels of these genes changed significantly after SALL4 knockdown, which ubiquitously led to cell apoptosis Q-RT-PCR shows differentially regulated expression levels of apoptotic genes in SALL4 knockdown NB4 cells.Human acute promyelocytic leukemia NB4 cells