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EGFR — SEC14L2
Text-mined interactions from Literome
Nishi et al., J Biol Chem 2001
:
However, our results indicate that
TAp63gamma has a very low ability to bind to the EGFRp53RE and surprisingly
represses both basal
EGFR promoter activity and endogenous EGFR expression ... Transient transfection assays show that the EGFR promoter region between -348 and -293, containing two Sp1 sites, is crucial for the
repression of the
EGFR expression by
TAp63gamma ... These results suggest that
TAp63gamma is
involved in the regulation of the
EGFR gene expression through interactions with basal transcription factors
Klanrit et al., Oncogene 2009
(Head and Neck Neoplasms) :
Expression of
TAp73beta efficiently induced promyelocytic leukaemia (PML) protein expression and PML knockdown by shRNA
attenuated the downregulation of
EGFR and induction of apoptosis by p73 in HNSCC cells