Gene interactions and pathways from curated databases and text-mining

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ANGPT2 — SHC1

Text-mined interactions from Literome

Wang et al., J Biol Chem 1999 : Nitric oxide did not affect either EGF receptor phosphorylation or Shc-Grb2 activation induced by either Ang II or EGF
Bokemeyer et al., Kidney Int 2000 (Coronary Artery Disease...) : Furthermore, Ang II induced the binding of the adaptor protein Shc to the EGFR, leading to phosphorylation of Shc
Sun et al., American journal of physiology. Renal physiology 2010 (Diabetes Mellitus, Experimental) : In vitro, HG and ANG II led to an increased expression of total and p-p66Shc in HK-2 cells
Sadoshima et al., EMBO J 1996 : Ang II causes rapid tyrosine phosphorylation of Shc and its association with Grb2 and mSos-1, a guanine nucleotide exchange factor of p21 ras
Zou et al., Circ Res 1998 : Ang II rapidly induced phosphorylation of Shc and association of Shc with Grb2
Eguchi et al., J Biol Chem 1998 : In the present study, we found Ang II rapidly induced the tyrosine phosphorylation of the epidermal growth factor (EGF) receptor and its association with Shc and Grb2
Li et al., EMBO J 1998 : In PKC depleted cells, Ang II stimulated Shc and Cbl tyrosine phosphorylation, suggesting that without PKC, Ang II activates another tyrosine kinase
Jiao et al., Proc Natl Acad Sci U S A 1998 : Moreover, Ang II and arachidonic acid induced an association between p21ras and Shc