Gene interactions and pathways from curated databases and text-mining

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SETD2 — SLC2A1

Text-mined interactions from Literome

Hoskin et al., Br J Cancer 2003 (Anoxia...) : Glucose transporter-1 protein (GLUT1) and carbonic anhydrase IX (CAIX) are regulated by hypoxia inducible factor-1 (HIF-1) and have been studied as putative intrinsic cellular markers for hypoxia
Hayashi et al., J Endocrinol 2004 (Anoxia) : Hypoxia-inducible factor-1 (HIF-1)alpha is involved in the induction of GLUT1 expression in other cells
Chau et al., Cancer Res 2005 : Interestingly, NSC-134754 but not NCS-643735 inhibited HIF-1 activity and HIF-1alpha protein induced by hypoxia and significantly inhibited Glut-1 expression
Schuster et al., Am J Physiol Lung Cell Mol Physiol 2007 : Inhibitors of p38 and HIF-1 blocked GLUT-1 translocation and [ 3H ] DG uptake
Bouquet et al., J Cell Sci 2011 : Importantly, in using either silenced DNA-PK cells or cells exposed to a specific DNA-PK inhibitor ( NU7026 ), we demonstrated that hypoxic DNA-PK activation positively regulates the key transcription factor HIF-1 and one subsequent target gene, GLUT1
Marsboom et al., Am J Respir Crit Care Med 2012 (Disease Models, Animal...) : HIF-1a mediated Glut1 up-regulation in proliferating vascular cells in PAH accounts for increased lung FDG-PET uptake
Lokmic et al., Int Rev Cell Mol Biol 2012 (Anoxia...) : HIF-1 transcriptionally upregulates expression of metabolic proteins ( GLUT-1 ), adhesion proteins ( integrins ), soluble growth factors ( TGF-ß and VEGF ), and extracellular matrix components ( type I collagen and fibronectin ), which enhance the repair process
Begley et al., EMBO Mol Med 2013 (Colonic Neoplasms) : Additionally, SW620 cells re-expressing hTRM9L did not respond to hypoxia via HIF1-a dependent induction of GLUT1
Dubey et al., J Am Chem Soc 2013 (Breast Neoplasms...) : It effectively inhibits HIF1 induced activation of VEGFA, LOX, Glut1 , and c-Met genes in a panel of cell lines representing breast and lung cancers
Smith et al., Nucl Med Biol 2013 : Molecular analysis indicated that hypoxia upregulated glut1 and 6-phosphofructo-2-kinase, key proteins involved in regulating glucose transport and glycolysis, and that these changes were induced by Hypoxia-Inducible factor 1 (HIF1) upregulation and/or AMP activated protein kinase activation
Straus et al., Molecular cancer 2013 (Colorectal Neoplasms) : Experiments with inhibitors indicated that HIF-1a played a role in induction of SLC2A1 and that the transcription factor NF-?B played a role in induction of hexokinase-2 by TNFa and IL-17