◀ Back to SETD2
SETD2 — SLC2A1
Text-mined interactions from Literome
Hoskin et al., Br J Cancer 2003
(Anoxia...) :
Glucose transporter-1 protein (GLUT1) and carbonic anhydrase IX (CAIX) are
regulated by
hypoxia inducible factor-1 (HIF-1) and have been studied as putative intrinsic cellular markers for hypoxia
Hayashi et al., J Endocrinol 2004
(Anoxia) :
Hypoxia-inducible factor-1 (HIF-1)alpha is
involved in the induction of
GLUT1 expression in other cells
Chau et al., Cancer Res 2005
:
Interestingly, NSC-134754 but not NCS-643735 inhibited
HIF-1 activity and HIF-1alpha protein induced by hypoxia and significantly
inhibited Glut-1 expression
Schuster et al., Am J Physiol Lung Cell Mol Physiol 2007
:
Inhibitors of p38 and
HIF-1 blocked
GLUT-1 translocation and [ 3H ] DG uptake
Bouquet et al., J Cell Sci 2011
:
Importantly, in using either silenced DNA-PK cells or cells exposed to a specific DNA-PK inhibitor ( NU7026 ), we demonstrated that hypoxic DNA-PK activation positively
regulates the key transcription factor
HIF-1 and one subsequent target gene,
GLUT1
Marsboom et al., Am J Respir Crit Care Med 2012
(Disease Models, Animal...) :
HIF-1a mediated
Glut1 up-regulation in proliferating vascular cells in PAH accounts for increased lung FDG-PET uptake
Lokmic et al., Int Rev Cell Mol Biol 2012
(Anoxia...) :
HIF-1 transcriptionally
upregulates expression of metabolic proteins (
GLUT-1 ), adhesion proteins ( integrins ), soluble growth factors ( TGF-ß and VEGF ), and extracellular matrix components ( type I collagen and fibronectin ), which enhance the repair process
Begley et al., EMBO Mol Med 2013
(Colonic Neoplasms) :
Additionally, SW620 cells re-expressing hTRM9L did not respond to hypoxia via
HIF1-a dependent induction of
GLUT1
Dubey et al., J Am Chem Soc 2013
(Breast Neoplasms...) :
It effectively inhibits
HIF1 induced activation of VEGFA, LOX,
Glut1 , and c-Met genes in a panel of cell lines representing breast and lung cancers
Smith et al., Nucl Med Biol 2013
:
Molecular analysis indicated that hypoxia upregulated
glut1 and 6-phosphofructo-2-kinase, key proteins involved in regulating glucose transport and glycolysis, and that these changes were
induced by
Hypoxia-Inducible factor 1 (HIF1) upregulation and/or AMP activated protein kinase activation
Straus et al., Molecular cancer 2013
(Colorectal Neoplasms) :
Experiments with inhibitors indicated that
HIF-1a played a role in induction of
SLC2A1 and that the transcription factor NF-?B played a role in induction of hexokinase-2 by TNFa and IL-17