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LEP — SLC2A4

Text-mined interactions from Literome

Berti et al., Mol Cell Endocrinol 1999 : PD98059, an ERK2 kinase-1 inhibitor, and wortmannin, an inhibitor of phosphatidylinositol 3-kinase blocked the leptin induced increase in glucose uptake and GLUT4 recruitment to the cell surface
Benomar et al., Endocrinology 2006 : Insulin and leptin induce Glut4 plasma membrane translocation and glucose uptake in a human neuronal cell line by a phosphatidylinositol 3-kinase- dependent mechanism ... We show that insulin and leptin both induce Glut4 translocation to the PM of neuronal cells and activate glucose uptake ... Wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase, totally abolished insulin- and leptin dependent Glut4 translocation and stimulation of glucose uptake ... A cross-desensitization between insulin and leptin was apparent, where exposure to insulin affects leptin dependent Glut4 translocation and vice versa
Tang et al., Br J Pharmacol 2010 : Curcumin suppressed the leptin induced membrane translocation of GLUT4 by interrupting the insulin receptor substrates/phosphatidyl inositol 3-kinase/AKT signalling pathway