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IL8 — SMAD3

Text-mined interactions from Literome

Verrecchia et al., J Biol Chem 2003 : We demonstrate that, in a cellular context devoid of JNK activity ( i.e. jnk ( -/- ) fibroblasts ), interleukin-1 and tumor necrosis factor-alpha (TNF-alpha) did not inhibit the formation of SMAD-DNA complexes and the resulting SMAD-driven transcription in response to TGF-beta
Perez et al., Am J Physiol Lung Cell Mol Physiol 2007 (Cystic Fibrosis...) : Continuous inhibition of CFTR-Cl ( - ) conductance for 3-5 days resulted in significant increase in IL-8 secretion at basal ( P = 0.006 ) and in response to 10 ( 9 ) Pseudomonas ( P = 0.0001 ), a fourfold decrease in Smad3 expression ( P = 0.02 ), a threefold increase in RhoA expression, and increased NF-kappaB nuclear translocation upon TNF-alpha/IL-1beta stimulation ( P < 0.000001 )
Gupta et al., Cancer Biol Ther 2011 (Bone Neoplasms...) : TGFß dependent induction of interleukin-11 and interleukin-8 involves SMAD and p38 MAPK pathways in breast tumor models with varied bone metastases potential