Gene interactions and pathways from curated databases and text-mining

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RELA — SMAD6

Text-mined interactions from Literome

Arsura et al., Oncogene 2003 (Carcinoma, Hepatocellular...) : Transient activation of NF-kappaB through a TAK1/IKK kinase pathway by TGF-beta1 inhibits AP-1/SMAD signaling and apoptosis : implications in liver tumor formation
Saika et al., Am J Pathol 2005 (Burns, Chemical...) : Expression of exogenous Smad7 in burned corneal tissue resulted in reduced activation of Smad signaling and nuclear factor-kappaB signaling via RelA/p65
Tzimas et al., Cell Signal 2006 : Overexpression of USP31 in HEK 293T cells inhibited TNFalpha, CD40, LMP1, TRAF2, TRAF6 and IKKbeta mediated NF-kappaB activation, but did not inhibit Smad mediated transcription activation
Eliseev et al., Exp Cell Res 2006 (Bone Neoplasms...) : Here, we show that in osteosarcoma Saos2 osteoblasts, NFkappaB regulates the activity of the BMP/Smad signaling ... We therefore conclude that in osteosarcoma Saos2 cells, NFkappaB represses BMP/Smad signaling and BMP2 induced differentiation through Smad7
Grau et al., Cell Signal 2006 (Colonic Neoplasms) : Role of Smad proteins in the regulation of NF-kappaB by TGF-beta in colon cancer cells
Li et al., J Bone Miner Res 2007 (Osteoporosis) : The effect of TNFalpha induced NF-kappaB signaling on Smad signaling and on in vitro osteoblast mineralization was examined using specific NF-kappaB inhibitors and activators, and effects of TNFalpha induced NF-kappaB signaling on BMP-2 induced Runx2 mRNA were examined using RT-PCR
Graham et al., Prostate 2009 (Neoplasm Metastasis...) : PI3K/Akt dependent transcriptional regulation and activation of BMP-2-Smad signaling by NF-kappaB in metastatic prostate cancer cells ... In this study, we investigated whether the nuclear transcription factor NF-kappaB , implicated in PC metastasis, is involved in transcriptional regulation and activation of BMP-2 or BMP-4/Smad signaling in PC cells ... Notably, the activation of BMPRII by BMP-2 is required for modulation of Smad activation by NF-kappaB in PC cells