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FAS — SMPD2

Text-mined interactions from Literome

Watanabe et al., Cancer Res 2004 : A caspase-3 inhibitor, acetyl-Asp-Glu-Val-Asp-chloromethyl ketone, blocked not only Fas induced increases of apoptosis and ceramide content but also Fas induced activation of nSMase and inhibition of SM synthase in the nuclear fraction
Cifone et al., EMBO J 1995 (Lymphoma) : Activation of a phosphatidylcholine-specific phospholipase C ( PC-PLC ) was also detected which appeared to be a requirement for subsequent acidic sphingomyelinase (aSMase) activation, since PC-PLC inhibitor D609 blocked Fas/APO-1 induced aSMase activation, but not Fas/APO-1 induced neutral sphingomyelinase (nSMase) activation