Leick et al., Exp Gerontol 2010
:
In conclusion, the present findings indicate that PGC-1alpha is required for training induced prevention of an age associated decline in CS activity and SOD2 protein expression in skeletal muscle
Marmolino et al., PloS one 2010
(Friedreich Ataxia) :
PGC-1alpha activation with the PPARgamma agonist ( Pioglitazone ) or with a cAMP dependent protein kinase (AMPK) agonist ( AICAR ) restored normal SOD2 induction