Gene interactions and pathways from curated databases and text-mining

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LEP — SP1

Text-mined interactions from Literome

Lin et al., Mol Endocrinol 2006 : An EMSA revealed that leptin enhanced specificity protein 1 (Sp1) binding ... Chromatin immunoprecipitation revealed that leptin enhanced binding of Sp1 ; however, inhibition of signal transducer and activator of transcription ( STAT ) 3 phosphorylation by AG490 also blocked Sp1 phosphorylation and significantly reduced leptin associated TIMP-1-229 promoter activity, indicating that one mechanism for leptin increased transcriptional activity is via phosphorylation of Sp1 and subsequent promoter binding ... Finally, we demonstrate that leptin also results in intranuclear pSTAT3 binding to Sp1
Moreno-Aliaga et al., J Mol Endocrinol 2007 : Together, these findings support a key role for Sp1 in the transcriptional activation of the leptin gene promoter by insulin mediated glucose metabolism
Gonzalez-Perez et al., Cell Signal 2010 (Mammary Neoplasms, Experimental) : SP1 was involved in leptin regulation of VEGF in 4T1 cells
García-Ruiz et al., Endocrinology 2012 (Fibrosis) : Gel retardation assays demonstrated that leptin induced the binding of transcription factors specific protein (Sp)-1 and Sp3 to two elements located between -161 and -110 bp of the Col1a(I) promoter ... Leptin induced Sp1/Sp3 phosphorylation, but this effect was suppressed by inhibiting or silencing Janus kinase-2, phosphatidylinositol-3-kinase, nonphagocytic adenine dinucleotide phosphate ( NADPH ) oxidase, or ERK1/2, by the use of antioxidants or catalase, or by preventing protein-aldehyde adduct formation