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LEP — SP1
Text-mined interactions from Literome
Lin et al., Mol Endocrinol 2006
:
An EMSA revealed that
leptin enhanced
specificity protein 1 (Sp1) binding ... Chromatin immunoprecipitation revealed that
leptin enhanced binding of
Sp1 ; however, inhibition of signal transducer and activator of transcription ( STAT ) 3 phosphorylation by AG490 also blocked Sp1 phosphorylation and significantly reduced leptin associated TIMP-1-229 promoter activity, indicating that one mechanism for leptin increased transcriptional activity is via phosphorylation of Sp1 and subsequent promoter binding ... Finally, we demonstrate that
leptin also
results in intranuclear pSTAT3 binding to
Sp1
Moreno-Aliaga et al., J Mol Endocrinol 2007
:
Together, these findings support a key
role for
Sp1 in the transcriptional activation of the
leptin gene promoter by insulin mediated glucose metabolism
Gonzalez-Perez et al., Cell Signal 2010
(Mammary Neoplasms, Experimental) :
SP1 was
involved in
leptin regulation of VEGF in 4T1 cells
García-Ruiz et al., Endocrinology 2012
(Fibrosis) :
Gel retardation assays demonstrated that
leptin induced the binding of transcription factors
specific protein (Sp)-1 and Sp3 to two elements located between -161 and -110 bp of the Col1a(I) promoter ...
Leptin induced
Sp1/Sp3 phosphorylation, but this effect was suppressed by inhibiting or silencing Janus kinase-2, phosphatidylinositol-3-kinase, nonphagocytic adenine dinucleotide phosphate ( NADPH ) oxidase, or ERK1/2, by the use of antioxidants or catalase, or by preventing protein-aldehyde adduct formation