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EPHB2 — SYN3
Text-mined interactions from Literome
Gao et al., Arthritis Res Ther 2006
(Arthritis, Experimental) :
Cultivation of mouse synovial fibroblasts with IL-1beta activates mitogen activated protein kinases, including extra-cellular signal regulated kinase ( Erk ), JNK ( c-Jun N-terminal kinase ), and p38, while only
Erk-specific inhibitor
blocks IL-1beta induced
SYN expression ... Inhibition of
Erk activation
reduces ETS1 phosphorylation and
SYN expression
Giachello et al., J Cell Sci 2010
:
However, the physiological role of
MAPK/Erk dependent
synapsin phosphorylation in regulating synaptic formation and function is poorly understood ... Our findings show that
MAPK/Erk dependent
synapsin phosphorylation has a dual role both in the establishment of functional synaptic connections and their short-term plasticity, indicating that some of the multiple extranuclear functions of MAPK/Erk in neurons can be mediated by the same multifunctional presynaptic target