Gene interactions and pathways from curated databases and text-mining

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MDM2 — TCF19

Text-mined interactions from Literome

Blagosklonny et al., Oncogene 2001 : Thus, Mdm-2 targets the p53 tumor suppressor for ubiquitin dependent degradation by the proteasome, but, in addition, the p53 transcription factor induces Mdm-2 , thus, establishing a feedback loop
Vargas et al., Adv Cancer Res 2003 (Neoplasms) : In response to stress, however, p53 is not affected by Mdm2 and functions as a transcription factor that induces the transcription of Mdm2 as well as of genes involved in growth control or apoptosis
Carroll et al., Cancer Res 2008 (Carcinoma, Renal Cell...) : The oncogene HDM2 has been implicated in the regulation of the transcription factor , hypoxia inducible factor ( HIF )
Xu et al., Cell 2009 (Retinoblastoma) : Interestingly, retinoblastoma cell MDM2 expression was regulated by the cone-specific RXRgamma transcription factor and a human-specific RXRgamma consensus binding site, and proliferation required RXRgamma, as well as the cone-specific thyroid hormone receptor-beta2