Gene interactions and pathways from curated databases and text-mining

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TIE1 — TNF

Text-mined interactions from Literome

DeBusk et al., Arthritis Rheum 2003 (Arthritis, Experimental...) : Primary cultured endothelial cells and synoviocytes were used to study tumor necrosis factor alpha (TNF alpha) induced Tie2 and Ang1 expression ... In addition, we observed that TNF alpha can regulate Tie2 activation in multiple ways that may involve interactions between endothelial cells and synoviocytes
Ogawara et al., Arthritis Res Ther 2006 : RGD targeted adenovirus delivered the dnIkappaB via alphavbeta3 to become functionally expressed, leading to complete abolishment of TNF-alpha induced up-regulation of E-selectin, ICAM-1, VCAM-1, IL-6, IL-8, VEGF-A and Tie-2
Yuan et al., Int J Artif Organs 2012 : TNF-a up-regulated the gene expression of VEGF, Angiopoietin-2, and Tie2 ( p < 0.05 )