Gene interactions and pathways from curated databases and text-mining

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TIRAP — TLR4

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Zhang et al., Infect Immun 2005 (Pseudomonas Infections) : We also determined that MyD88, IRAK, TRAF6, and Toll interacting protein (Tollip), but not TIRAP , were involved in the TLR mediated response to P. aeruginosa in HAECs
Sacre et al., Am J Pathol 2007 (Arthritis, Rheumatoid...) : Because TLR2 and TLR4 require both MyD88 and Mal/TIRAP for signaling, this study suggests that TLR function may regulate the expression of these factors in the RA synovium
Kagan et al., Nat Immunol 2008 : We propose that TLR4 first induces TIRAP-MyD88 signaling at the plasma membrane and is then endocytosed and activates TRAM-TRIF signaling from early endosomes
Weller et al., Blood 2012 : TLR4 and the TLR2 heterodimers ( with TLR1, TLR6, and possibly TLR10 ) require in addition the adaptor TIRAP , whereas UNC-93B is needed for the proper localization of intracellular TLR3, TLR7, TLR8, and TLR9