Gene interactions and pathways from curated databases and text-mining

◀ Back to IL8

IL8 — TLR5

Text-mined interactions from Literome

Dziarski et al., J Endotoxin Res 2000 : Therefore, TLR2 is a functional receptor for both Gram positive and Gram negative bacteria and it induces activation of IL-8
Rhee et al., J Biol Chem 2004 : MEK is a key modulator for TLR5 induced interleukin-8 and MIP3alpha gene expression in non transformed human colonic epithelial cells
Khan et al., Immunology 2004 : The role of TLR5 in p38 MAPK dependent IL-8 secretion was verified in HEp-2 cells transiently transfected with a TLR5 expression construct ... Collectively, our results suggest that TLR5 mediates p38 MAPK dependent IL-8 secretion from epithelial and monocytic cells incubated with FliC-EAEC, and that this effect requires IL-8 promoter activation independent of NF-kappaB nuclear migration
Torok et al., Infect Immun 2005 : Secretion of IL-8 from H. pylori infected HEK293 cells was augmented by the expression of TLR2 or TLR5
Köllisch et al., Immunology 2005 : The TLR ligands peptidoglycan, Pam3Cys and flagellin which bind to TLR2, TLR1/TLR2 heterodimer, and TLR5, respectively, also induced IL-8 secretion, whereas no IL-8 was induced by LPS, R-848, loxoribine and cytosine guanine dinucleotide containing oligodeoxynucleotide
Raffatellu et al., Infect Immun 2005 : Collectively, these data suggest that the scarcity of neutrophils in intestinal infiltrates of typhoid fever patients is due to a capsule mediated reduction of TLR dependent IL-8 production in the intestinal mucosa
Kramer et al., J Leukoc Biol 2006 (Crohn Disease) : Moreover, they lack MDP induced enhancement of TLR mediated tumor necrosis factor alpha, interleukin (IL)-12 , and IL-10 production, which is observed in control DC with intact NOD2
Lu et al., J Immunol 2006 (Pneumonia, Bacterial...) : Expression of MUC1 in HEK293T cells attenuated TLR5 dependent IL-8 release in response to flagellin, which was completely ablated when its cytoplasmic tail was deleted
Mueller et al., J Immunol 2006 : TLR4/MD-2 mediated LPS uptake and TLR ligand induced I-kappaBalpha phosphorylation and IL-8 secretion were significantly diminished in Th2 cytokine primed IECs
Du et al., Invest Ophthalmol Vis Sci 2006 (MAP Kinase Signaling System) : AsialoGM1 mediated IL-8 release by human corneal epithelial cells requires coexpression of TLR5
Cho et al., Immunol Lett 2007 (Arthritis, Rheumatoid) : Thus, TLR-2 activation in RA FLS by microbial constituents could be involved in the induction of VEGF and IL-8 and thereby promote inflammation either directly or via angiogenesis
Uehara et al., Mol Immunol 2007 : Anti-RP3 Abs markedly promoted the release of IL-8 induced by chemically synthesized TLR and NOD ligands mimicking bacterial components : TLR2-agonistic lipopeptide ( FSL-1 ), TLR3-agonistic poly I:C, TLR4-agonistic lipid A ( LA-15-PP ), TLR7/8-agonistic single stranded RNA ( ssPolyU ), TLR9-agonistic bacterial CpG DNA, NOD1-agonistic FK156/565 and NOD2-agonistic muramyldipeptide ( MDP ) in THP-1 cells and human peripheral blood mononuclear cells, although sole incubation with anti-PR3 Abs induced only a low level of IL-8
Kanczkowski et al., Horm Metab Res 2007 (Adrenal Cortex Neoplasms) : The aim of this study was to clarify the role of different TLR ligands in IL8 production in NCI-H295R cells
Koff et al., Am J Physiol Lung Cell Mol Physiol 2008 : We conclude that multiple TLR ligands induce airway epithelial cell production of IL-8 and VEGF via a Duox1 -- > ROS -- > TACE -- > TGF-alpha -- > EGFR phosphorylation pathway
Buchholz et al., Infect Immun 2008 (Inflammation) : IL-8 induced at 30 h postinfection by C. trachomatis was dependent on NOD1 signaling through RIP2 ; however, the IL-8 response was independent of MyD88 dependent TLR signaling
Wang et al., Blood 2008 : We and others have reported that Toll-like receptor ( TLR ) proteins are present on human neutrophils and that granulocyte-macrophage colony stimulating factor ( GM-CSF ) treatment enhances IL-8 ( CXCL8 ) secretion in response to stimulation with TLR ligands
Harrison et al., Infect Immun 2008 : Bacterial flagellins are known to induce IL-8 production through Toll-like receptor 5 (TLR5)
Schüller et al., Cell Microbiol 2009 : Immunofluorescence staining of EPEC infected small intestinal biopsies revealed apical and basolateral distribution of Toll-like receptor (TLR) 5 on epithelium, suggesting that EPEC can trigger mucosal IL-8 responses by apical flagellin/TLR5 interaction ex vivo and does not require access to the basolateral membrane as postulated in cell culture models
Berndt et al., Equine Vet J 2009 (Airway Obstruction...) : In human airway epithelium, TLR2 activation leads to interleukin (IL)-8 production
Lee et al., J Parasitol 2010 : We also performed reverse transcriptase-polymerase chain reaction ( RT-PCR ) and flow cytometry to determine whether TLR and MUC expression is regulated by interferon (IFN)-gamma, interleukin-4 , or monoclonal antibodies ( mAbs ) against G. seoi 46 kDa antigen
Im et al., Mol Immunol 2009 : Collectively, these results suggest that flagellin induced IL-8 expression requires formation of lipid rafts, intracellular TLR activation, and subsequent activation of PKC and MAP kinases leading to the activation of the transcription factors NF-kappaB and NF-IL6 in human alveolar type II epithelial cells
Suzuki et al., J Dent Res 2009 (Gingival Overgrowth) : In human gingival fibroblasts, cyclosporin alone did not induce evident inflammatory responses, but augmented the expression of CD54 and the production of interleukin (IL)-6 and IL-8 induced by TLR ligands, whereas phenytoin attenuated those responses
Manuse et al., Virology 2010 : Unexpectedly, TLR3 activation in infected cells led to enhanced IL-8 secretion, which correlated with increased RIG-I expression
Khan et al., J Immunol 2010 : Conversely, stable overexpression of Sigirr diminished NF-kappaB mediated IL-8 responses to TLR ligands
Han et al., Vet Microbiol 2010 : Involvement of TLR21 in baculovirus induced interleukin-12 gene expression in avian macrophage-like cell line HD11
Devriendt et al., Dev Comp Immunol 2010 (Diarrhea...) : Indeed, porcine IEC express TLR5 and purified flagellin induced IL-6 and IL-8 secretion, indicating that, as for other pathogens, flagellin is the dominant virulence factor involved in the induction of proinflammatory responses in IEC
Piconi et al., AIDS 2010 (HIV Infections) : Activated T cells ( Ki67 ( + ) ), Treg lymphocytes ( CD4 ( + ) /CD25high/Foxp3+ ), divided into naive and activated cells based on PD1 expression, interleukin (IL)-10 and transforming growth factor ( TGF ) -beta production, annexin V, activation of caspases 8 and 9, Toll-like receptor (TLR)2 and TLR4 expression on immune cells, and plasma lipopolysaccharide (LPS) concentration were analyzed
Chung et al., J Infect Dis 2010 (Hepatitis C, Chronic) : Alloantigen presentation by monocytes isolated from HCV infected patients results in impaired production of interleukin 17 by naive CD4 ( + ) T cells in the presence of TLR ligands
Li et al., Int J Mol Med 2011 : In addition, Atg7 gene expression silencingled to down-regulation of TLR mediated IL-8 expression in IECs, which indicates a potential role of autophagy in generating innate-immune responses
Song et al., Viral Immunol 2011 : Taken together, the results suggest that IL-8 , IP-10, and GRO-a are predominantly induced in respiratory epithelial cells infected with influenza A viruses, and that TLR-5 and TLR-3 are involved in the stimulation of virus infected respiratory epithelial cells
Eaves-Pyles et al., PloS one 2011 (Inflammation) : Silencing or blocking TLR5 in Caco-2BBe cells resulted in a lack of flagellin internalization and decreased IL-8 secretion
Qian et al., Aging Cell 2012 (Inflammation) : Using a multivariable mixed effect model, we report a highly significant increase in TLR5 induced production of IL-8 from monocytes of older individuals ( P < 0.0001 )
Hanamsagar et al., Trends Immunol 2012 : TLR signaling triggers the transcriptional activation of pro-interleukin-1ß ( pro-IL-1ß ) and pro-IL-18 that are processed into their active forms by the inflammasome
Ben Mohamed et al., PloS one 2012 (Pseudomonas Infections) : Silencing of TLR5 and Naip, siRNA inhibited both flagellin induced MUC5AC expression and IL-8 secretion
Li et al., eLife 2012 : A sequence containing 13 nucleotides near the active site of 23S rRNA ribozyme, which catalyzes peptide bond synthesis, was both necessary and sufficient to trigger TLR13 dependent interleukin-1ß production
Koblansky et al., Immunity 2013 (Genetic Predisposition to Disease...) : Toll-like receptor 11 ( TLR11 ) recognizes T. gondii profilin ( TgPRF ) and is required for interleukin-12 production and induction of immune responses that limit cyst burden in Toxoplasma gondii infected mice
Schamber-Reis et al., J Biol Chem 2013 (Disease Resistance...) : Altogether, our results indicate the redundant and essential role of nucleic acid sensing TLR3, TLR7 and TLR9 in inducing interleukin 12, development of a T1 response, and resistance to L. major infection in resistant C57BL/6 mice