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TLR2 — TRAF7
Text-mined interactions from Literome
Yoshida et al., J Biol Chem 2005
(Inflammation) :
We showed that activation of
TLR2 signaling by TLR2 ligands including peptidoglycan ( PGN ), MALP-2, and Pam3CSK4
induces activation of IKKs-IkappaBalpha and MKK3/6-p38 pathways not only by TRAF6 but also by
TRAF7 , a recently identified TRAF family member
Clark et al., Proc Natl Acad Sci U S A 2011
:
Toll-like receptor ( TLR ) ligands that signal via TIR-domain containing adapter inducing IFNß ( TRIF )
activate the I?B kinase ( IKK ) -related kinases,
TRAF associated NF?B activator ( TANK) binding kinase-1 (TBK1 ) and IKKe, which then phosphorylate IRF3 and induce the production of IFNß