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Moniz et al., Oncogene 2007
:
Furthermore, expression of a kinase-dead WNK2-K207M mutant also activated ERK1/2 suggesting that WNK2 catalytic activity is required
Moniz et al., Cell Signal 2008
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Here we provide mechanistic insight into how WNK2 affects ERK activation
Zheng et al., Chin J Integr Med 2010
(Brain Ischemia...) :
Furthermore, WNK inhibited GRK2 translocation from cytosol to the membrane ( at 20 mg/kg ) and reduced ERK1/2 phosphorylation and MMP-9 expression in cortical microvessels