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PIK3R1 — XIAP

Text-mined interactions from Literome

Carter et al., Leukemia 2003 (Blast Crisis...) : Neither these nor Akt inhibitor treated OCI-AML3 cells showed changes in XIAP levels, suggesting that XIAP expression is regulated by PI3K downstream effectors other than Akt
Paling et al., J Biol Chem 2004 : Treatment with the reversible PI3K inhibitor, LY294002, or more specific inhibition of class I ( A ) PI3K via regulated expression of dominant negative Deltap85, led to a reduction in the ability of LIF to maintain self-renewal, with cells concomitantly adopting a differentiated morphology
Iwase et al., Int J Oncol 2007 (Carcinoma, Squamous Cell...) : Expression of Bcl-2, cellular inhibitor of apoptosis protein-1 ( cIAP-1 ), and X-linked IAP was down-regulated, and expression of Bax was up-regulated by PI 3-K inhibitors, while that of Bcl-xL, Bak and cIAP-2 was not attenuated
Wang et al., Cancer Lett 2010 (Ovarian Neoplasms) : Meanwhile, the further study demonstrates that the chemoresistance caused by IL-6 is associated with increased expression of both multidrug resistance related genes ( MDR1 and GSTpi ) and apoptosis inhibitory proteins ( Bcl-2, Bcl-xL and XIAP ), as well as activation of Ras/MEK/ERK and PI3K/Akt signaling
Zhang et al., Front Biosci (Elite Ed) 2011 : Taken together, the present study demonstrates that T3 potentiates the cell survival action of FSH through Src- and PI3K mediated Xiap up-regulation and decreased Fas and FasL expression
Veillette et al., Biol Reprod 2013 : PI3-K inhibition in vivo blocked Akt phosphorylation, reduced Smad2 phosphorylation, and reduced both TGF-beta2 and XIAP expression