Gene interactions and pathways from curated databases and text-mining

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ACP2 — IL6

Text-mined interactions from Literome

Niehof et al., J Biol Chem 2001 : Here we show that IL-6 controls LAP/C/EBPbeta gene transcription and identify an IL-6 responsive element in the LAP/C/EBPbeta promoter, which contains no STAT3 DNA binding motif ... However, luciferase reporter gene assays showed that STAT3 activation through the gp130 signal transducer molecule is involved in mediating IL-6 dependent LAP/C/EBPbeta transcription ... Further analysis using STAT1/STAT3 chimeras identified specific domains of the protein that are required for the IL-6 dependent increase in LAP/C/EBPbeta gene transcription ... Overexpression of the amino-terminal domain of STAT3 blocked the IL-6 mediated response, suggesting that the STAT3 amino terminus has an important function in IL-6 mediated transcription of the LAP/C/EBPbeta gene ... These data lead to a model of how tethering STAT3 to a DNA bound complex contributes to IL-6 dependent LAP/C/EBPbeta gene transcription
Hocke et al., Mol Cell Biol 1992 (Carcinoma, Hepatocellular...) : One class of genes coding for the acute-phase proteins ( acute-phase genes ) is induced by interleukin 6 (IL-6) through the human transcription factor NF-IL-6 and its rat homolog IL-6-DBP/LAP
Su et al., J Biol Chem 2003 : Here we report that LPS induced expression of IL-6 gene in P388D1 cells is mediated by a redox switch activated LAP*
Reddi et al., FEMS Immunol Med Microbiol 1995 : In response to LAP from Prev. intermedia, IL-6 was produced by mono-mac-6 cells but not by fibroblasts
Trautwein et al., Nature 1993 : Also, NF-IL6/LAP is involved in the activation of the IL-6 promoter in response to IL-1 and bacterial lipopolysaccharide