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ACP2 — IL6
Text-mined interactions from Literome
Niehof et al., J Biol Chem 2001
:
Here we show that
IL-6 controls
LAP/C/EBPbeta gene transcription and identify an IL-6 responsive element in the LAP/C/EBPbeta promoter, which contains no STAT3 DNA binding motif ... However, luciferase reporter gene assays showed that STAT3 activation through the gp130 signal transducer molecule is involved in mediating
IL-6 dependent
LAP/C/EBPbeta transcription ... Further analysis using STAT1/STAT3 chimeras identified specific domains of the protein that are required for the
IL-6 dependent increase in
LAP/C/EBPbeta gene transcription ... Overexpression of the amino-terminal domain of STAT3 blocked the IL-6 mediated response, suggesting that the STAT3 amino terminus has an important function in
IL-6 mediated transcription of the
LAP/C/EBPbeta gene ... These data lead to a model of how tethering STAT3 to a DNA bound complex contributes to
IL-6 dependent
LAP/C/EBPbeta gene transcription
Hocke et al., Mol Cell Biol 1992
(Carcinoma, Hepatocellular...) :
One class of genes coding for the acute-phase proteins ( acute-phase genes ) is
induced by
interleukin 6 (IL-6) through the human transcription factor NF-IL-6 and its rat homolog
IL-6-DBP/LAP
Su et al., J Biol Chem 2003
:
Here we report that LPS induced expression of
IL-6 gene in P388D1 cells is
mediated by a redox switch activated
LAP*
Reddi et al., FEMS Immunol Med Microbiol 1995
:
In
response to
LAP from Prev. intermedia,
IL-6 was produced by mono-mac-6 cells but not by fibroblasts
Trautwein et al., Nature 1993
:
Also,
NF-IL6/LAP is
involved in the activation of the
IL-6 promoter in response to IL-1 and bacterial lipopolysaccharide