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AHSA1 — PI3
Text-mined interactions from Literome
Bijur et al., J Neurochem 2000
:
Heat shock ( 45 degrees C ) rapidly activated Akt, extracellular signal regulated kinases 1 and 2 ( ERK1/2 ), and p38, but only Akt was activated in a
phosphatidylinositol 3-kinase (PI-3K) dependent manner, as the PI-3K inhibitors LY294002 and wortmannin blocked Akt activation, but not ERK1/2 or
p38 activation
Steven Zatechka et al., Exp Eye Res 2002
:
Both MEK and
p38 inhibitors
stimulated PI-3K
Gonzalez et al., Mol Cell Biol 2004
(MAP Kinase Signaling System) :
Complementary to p38 mediated transactivation of Akt, activation or inhibition of
PI 3-kinase regulated
p38 activity upstream of MKK6, demonstrating reciprocal communication and positive feedback characteristic of myogenic regulation
Tsai et al., Chem Res Toxicol 2004
(MAP Kinase Signaling System) :
This benzo [ a ] pyrene induced osteoblast proliferation could be inhibited by the estrogen receptor antagonist ICI182780 and tamoxifen, PD98059 [ extracellular signal regulated kinase ( ERK ) /mitogen activated protein kinase ( MAPK ) inhibitor ], and LY294002 [
phosphatidylinositol 3-kinase (PI3K) inhibitor ] but not alpha-naphthoflavone ( aryl hydrocarbon receptor antagonist ) and SB203580 (
p38 MAPK inhibitor )
Kukhtina et al., Biochemistry (Mosc) 2005
(MAP Kinase Signaling System) :
Selective inhibitors of Src-kinases and
PI3-kinases significantly
inhibited phosphorylation of
p38 but did not influence phosphorylation of ERK1/2 MAP-kinases
Nishiura et al., Apoptosis 2010
:
This alternative
p38MAPK activation could be pharmacologically
suppressed not only by the downregulation of
phosphoinositide 3-kinase (PI3K) by LY294002, but also by the over-activation of protein kinase C by phorbol 12-myristate 13-acetate