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APOB — IL8

Text-mined interactions from Literome

Sakurai et al., Kidney Int Suppl 1999 (Glomerulonephritis, Membranous...) : The effects of steroids and LDL-A on the production of IL-8 , TNF-alpha, and MCP-1 by peripheral blood mononuclear cells ( PBMCs ) were also determined in some patients
De Castellarnau et al., Arterioscler Thromb Vasc Biol 2000 : Electronegative LDL from normolipemic subjects induces IL-8 and monocyte chemotactic protein secretion by human endothelial cells ... LDL ( - ) increased , in a concentration dependent manner, the release of IL-8 and MCP-1 by ECs and was a stronger inductor of both chemokines than oxidized LDL ( oxLDL ) or LDL ( + ) ... Actinomycin D inhibited the release of IL-8 and MCP-1 induced by LDL ( - ) and oxLDL by up to 80 %, indicating that their production is mediated by protein synthesis ... Incubation of ECs with N : -acetyl cysteine inhibited production of IL-8 and MCP-1 induced by LDL ( - ) and oxLDL by > 50 %
Benítez et al., Circulation 2003 (Hypercholesterolemia...) : Electronegative LDL [ LDL ( - ) ], a modified subfraction of LDL present in plasma, induces the release of interleukin-8 and monocyte chemotactic protein-1 from cultured endothelial cells
Holm et al., Journal of thrombosis and haemostasis : JTH 2003 (Arteriosclerosis...) : Our main findings were : ( a) ox-LDL stimulated the release of the CXC-chemokines interleukin (IL)-8 , ENA-78 and GRO-alpha from PBMC, particularly in CAD
Ryoo et al., Cardiovasc Res 2004 : Native LDL induces interleukin-8 expression via H2O2, p38 Kinase, and activator protein-1 in human aortic smooth muscle cells ... LDL induced IL-8 expression ( mRNA and protein ) is specific to SMCs and likely to be regulated at the transcription level in dose- and time dependent manners, as judged by experiments with actinomycin D and ELISA
Ryoo et al., Biochem Biophys Res Commun 2004 : PPARalpha activation abolishes LDL stimulated IL-8 production via AP-1 deactivation in human aortic smooth muscle cells ... The findings of this study show, for the first time, that the peroxisome proliferator activated receptor ( PPARalpha ) agonist, fenofibrate, completely abolishes the LDL induced IL-8 up-regulation at the transcriptional level
Beaudeux et al., Clin Chim Acta 2004 (Inflammation) : The effects of PAF and oxidised LDL on the production of monocyte chemoattractant protein-1 and interleukin-8 were also examined
Tapiero et al., Biomed Pharmacother 2004 (Cardiovascular Diseases...) : In addition, Ox-LDL enhances the production and release of tumor necrosis factor ( TNF-alpha ), interleukin (IL)-6, arachidonic acid metabolites and nitric oxide ( NO ) that are responsible for various human pathologies including cancer
Dobreva et al., J Biol Chem 2006 (Atherosclerosis) : Furthermore, LDL induced IL-8 production and subsequent wound closure required the activation of the p38 MAPK pathway, because both processes were abrogated by a specific p38 inhibitor
Hakala et al., Arterioscler Thromb Vasc Biol 2006 (Inflammation) : Using cytokine cDNA arrays, we found that H-LDL induced expression of IL-8 , but not of the anti-inflammatory cytokines IL-10 and transforming growth factor ( TGF ) -beta, in human monocyte derived macrophages ... H-LDL induced rapid phosphorylation of the p38 mitogen activated protein kinase ( MAPK ), nuclear translocation of 2 transcription factors, nuclear factor kappaB (NF-kappaB) and activator protein 1 (AP-1), and time dependent secretion of IL-8 from the macrophages ... Inhibition of MAPKs and of transcription factors showed that p38 MAPK and NF-kappaB, but not ERK1/2, JNK, or AP-1, were crucial for the H-LDL induced IL-8 secretion from the macrophages
Heo et al., Biochem Biophys Res Commun 2007 : In previous studies, our group investigated the molecular mechanisms by which LDL induces IL-8 production and by which PPARalpha activation abolishes LDL effects in human aortic SMCs ( hAoSMCs )
Dorweiler et al., Thromb Haemost 2008 (Atherosclerosis) : In conclusion, LDL induced secretion of IL-8 by intimal smooth muscle cells provides a potential mechanism of PMN-recruitment into culprit lesions
Roumeguère et al., Eur Urol 2010 (Inflammation) : Two-way ANOVA analysis showed that TNF-alpha alone ( p < 0.001 ) or Mox-LDL alone ( p < 0.001 ) increased IL-8 production
Mattaliano et al., Am J Physiol Cell Physiol 2010 : ROCK2 associates with lectin-like oxidized LDL receptor-1 and mediates oxidized LDL induced IL-8 production
Geng et al., Mol Cell Biochem 2010 (Atherosclerosis) : TLR4 expression was inhibited by small interference RNA ( siRNA ) plasmid expression vectors ; NF-kappa B activity and the secretions of MCP-1 and IL-8 in response to ox-LDL were significantly lower in the group wherein TLR4 expression has been inhibited than that in the group wherein TLR4 expression has not been inhibited
Cheng et al., International journal of biological sciences 2013 : TLR4 siRNA showed stronger inhibition on AGE-LDL induced IL-6 and IL-8 production than that of TLR2 siRNA ... Silencing MyD88, but not TRIF, inhibited AGE-LDL induced IL-6 and IL-8 production ... Conclusion : AGE-LDL induced IL-6 and IL-8 production via TLR2/4-MyD88 dependent pathway in tubular epithelial cells
Claise et al., FEBS Lett 1996 : Oxidized LDL induced a 3-fold increase in IL-8 production ( p < 0.01 ), whereas RANTES was not detected ... Native LDL did not stimulate IL-8 production
Liu et al., Arterioscler Thromb Vasc Biol 1997 (Arteriosclerosis) : A specific stimulation of interleukin-8 (IL-8) production by oxidized LDL ( oxLDL ) has been shown by other investigators
Wooten et al., J Immunol 1998 : Lipoprotein mediated induction of nuclear factor-kappaB nuclear translocation and production of IL-8 and IL-6 in HUVEC was enhanced in the presence of serum or soluble rCD14