Gene interactions and pathways from curated databases and text-mining

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ATG12 — MTOR

Text-mined interactions from Literome

Huang et al., Int J Oncol 2013 : In SK-HEP-1 cells, kaempferol increased the protein levels of p-AMPK, LC3-II, Atg 5, Atg 7, Atg 12 and beclin 1 as well as inhibited the protein levels of CDK1, cyclin B, p-AKT and p-mTOR
Wang et al., J Ethnopharmacol 2013 (Ischemic Attack, Transient...) : HLJDD also notably elevated the levels of microtubule associated protein1 light chain 3 ( LC3 ), Beclin-1, and other autophagy related genes ( Atgs ) , promoted the activation of extracellular signal regulated kinases ( ERK ), protein kinase B ( Akt ), 3-phosphoinositide dependent kinase ( PDK1 ), and inhibited the activation of mammalian target of rapamycin (mTOR) , c-Jun N-terminal protein kinases (JNK), p38, phosphatase and tensin homolog (PTEN)