Doong et al., J Biol Chem 2003
(Breast Neoplasms) :
Human breast cancer cells were engineered to overexpress either full-length CAIR-1 ( FL ), which binds Hsp70, or a BAG domain-deletion mutant ( dBAG ) that can not bind Hsp70. FL overexpression prevented geldanamycin mediated loss of total and phospho-Akt and other Hsp client proteins
Rahman et al., J Biol Chem 2011
:
Silencer of death domains (SODD) inhibits skeletal muscle and kidney enriched inositol 5-phosphatase ( SKIP ) and regulates phosphoinositide 3-kinase (PI3K)/Akt signaling to the actin cytoskeleton