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BRCA1 — IGF2
Text-mined interactions from Literome
Shukla et al., Cancer Res 2006
(Mammary Neoplasms, Experimental) :
Furthermore, we provide evidence that
activation of
IGF signaling by
BRCA1 deficiency can also occur in a p53 independent fashion
Maor et al., Cancer Lett 2007
(Breast Neoplasms) :
To assess the potential inhibitory
role of
BRCA1 on
IGF-IR levels, we infected the BRCA1-deficient HCC1937 cell line with a BRCA1 encoding adenoviral vector ... Results of Western blots showed that
BRCA1 induced a large reduction in endogenous
IGF-IR levels
Schayek et al., Clin Cancer Res 2009
(Prostatic Neoplasms) :
Tumor suppressor
BRCA1 is expressed in prostate cancer and
controls insulin-like growth factor I receptor (
IGF-IR ) gene transcription in an androgen receptor dependent manner ... On the other hand,
BRCA1 enhanced
IGF-IR levels in LNCaP C4-2 cells expressing an endogenous AR ... We provide evidence that
BRCA1 differentially
regulates IGF-IR expression in AR-positive and AR-negative prostate cancer cells
Li et al., Frontiers in bioscience (Landmark edition) 2013
(Prostatic Neoplasms) :
BRCA1 can directly interact with the androgen receptor (AR) and Janus kinase ( JAK ), and can differentially
regulate insulin-like growth factor 1 receptor (
IGF-IR ) expression in an AR-dependent manner