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CCL2 — INS

Text-mined interactions from Literome

Aljada et al., Metabolism 2002 : We have recently demonstrated that insulin also inhibits the expression of intracellular adhesion molecule-1 ( ICAM-1 ) and monocyte chemoattractant protein-1 ( MCP-1 ), 2 major proinflammatory mediators, by human aortic endothelial cells ( HAEC ) and the proinflammatory mediator, nuclear factor ( NF-kappa B ), in the nucleus in parallel with an increase in endothelial nitric oxide synthase ( e-NOS ) expression
Sartipy et al., Proc Natl Acad Sci U S A 2003 (Insulin Resistance...) : It also shows that insulin induces substantial expression and secretion of MCP-1 both in vitro in insulin-resistant (IR) 3T3-L1 adipocytes and in vivo in IR obese mice ( ob/ob )
Sell et al., Endocrinology 2006 (Inflammation) : Among these candidates, MCP-1 alone impaired insulin signaling in skeletal muscle cells at doses similar to its physiological plasma concentrations ( 200 pg/ml ), whereas IL-6, IL-8, and macrophage inflammatory protein-1beta were effective at very high concentrations only
Sato et al., Diabetologia 2007 (Hyperinsulinism) : Insulin at a concentration of 10 nmol/l significantly stimulated the expression of Cebpb, Cebpd and Ccl2 mRNAs, depending on activation of phosphatidylinositol 3-kinase (PI3K) in cultured vascular smooth muscle cells ... The knock-down of C/EBP-beta with siRNA abolished the insulin induced Ccl2 mRNA expression
Westerbacka et al., Am J Physiol Endocrinol Metab 2008 (Insulin Resistance...) : Insulin regulation of MCP-1 in human adipose tissue of obese and lean women ... Insulin increases CCL2 expression in adipose tissue and in serum more in insulin-resistant obese than in insulin-sensitive lean mice, but whether this is true in humans is unknown ... We compared basal expression and insulin regulation of CCL2 and CCL3 in adipose tissue and MCP-1 and MIP-1alpha in serum between insulin-resistant and insulin-sensitive human subjects ... Insulin regulation of CCL2 differs between insulin-sensitive and -resistant subjects in a direction that could exacerbate adipose tissue inflammation
Engberding et al., Arterioscler Thromb Vasc Biol 2009 (Diabetes Mellitus, Type 2...) : IGF1R downregulation uncovered an insulin induced reduction in activation of NF-kappaB and inhibition of MCP-1 upregulation in response to TNF-alpha
Bian et al., J Leukoc Biol 1996 : High concentrations of glucose ( 20 mM ; 360 mg/dl ) increased GHSA induced hRPE IL-8 and MCP-1 secretion, whereas added insulin ( 0.5 ng/mL ) inhibited IL-8 but not MCP-1 protein secretion and mRNA expression
Gu et al., J Leukoc Biol 1997 : In contrast, another model in which MCP-1 expression was controlled by the insulin promoter demonstrated a monocytic infiltrate in pancreatic islets