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CCND1 — MAPK12

Text-mined interactions from Literome

Viñals et al., Mol Cell Biol 1999 : Enforced long-term activation of p42/p44 MAPK by expression of the chimera DeltaRaf-1 : ER, which activates the p42/p44 MAPK cascade at the level of Raf, enhanced the expression of MKP1/2 and cyclin D1 and, more importantly, restored the reentry of confluent cells into the cell cycle
Terada et al., Kidney Int 1999 : In contrast, overexpression of the active form of p42/44 MAPK-activator , MKK1, increased cyclin D1 and A promoter activity and protein levels
Corre et al., Oncogene 1999 (Cell Transformation, Viral...) : Expression of alpha i2-G204A resulted in decreased Src-kinase activity, delayed activation of p42 ERK-MAPK , decreased cyclin D1 expression and reduced proliferation in response to serum
Lotfi et al., Braz J Med Biol Res 2000 (Adrenal Cortex Neoplasms) : FGF2 elicits a strong mitogenic response in G0/G1 arrested Y1 adrenocortical cells, that includes a ) rapid and transient activation of extracellular signal regulated kinases-mitogen activated protein kinases ( ERK-MAPK) (2 to 10 min ), b ) transcription activation of c-fos, c-jun and c-myc genes ( 10 to 30 min ), c ) induction of c-Fos and c-Myc proteins by 1 h and cyclin D1 protein by 5 h, and d ) onset of DNA synthesis stimulation within 8 h. ACTH, itself a weak mitogen, interacts with FGF2 in a complex manner, blocking the FGF2 mitogenic response during the early and middle G1 phase, keeping ERK-MAPK activation and c-Fos and cyclin D1 induction at maximal levels, but post-transcriptionally inhibiting c-Myc expression
Martínez Muñoz et al., Cell Mol Life Sci 2001 : Activation of mitogen activated protein ( MAP ) kinase is essential for cyclin D1 expression and provides a link between mitogenic signalling and cell cycle progression
Lenferink et al., Cancer Res 2001 (Breast Neoplasms...) : Consequently, both MAPK dependent transcription of cyclin D1 and phosphorylation of the cyclin dependent kinase (Cdk) inhibitor p27 were inhibited
Tsang et al., Biochem Biophys Res Commun 2002 (MAP Kinase Signaling System) : PD098059 and U0126, two MAPK kinase inhibitors, and LY294002, a PI3K inhibitor, significantly blocked thrombin induced [ ( 3 ) H ] thymidine incorporation and cyclin D(1) expression in ASM cells
Timms et al., Oncogene 2002 (Breast Neoplasms...) : PI3K signalling also participated in cell cycle progression, since PI3K and MAPK coordinately regulated changes in cyclin D1 and cdk6 expression
D'Onofrio et al., J Neurochem 2003 (Glioma) : In cultures treated with EGF, LY341495 was also able to reduce the stimulation of the mitogen activated protein kinase ( MAPK ) pathway, as well as the induction of cyclin D1
Luo et al., Chin J Cancer 2003 (Hodgkin Disease...) : MAPK may induce overexpression of cyclin D1 protein and results in persistent proliferation of RS/H cells in genesis and development of HL
Kintscher et al., Biochem Biophys Res Commun 2003 (MAP Kinase Signaling System) : Therefore, we examined the involvement of p38 MAPK signaling in AngII stimulated DNA synthesis, phosphorylation of the retinoblastoma protein ( Rb ), and expression of the G1-phase cyclin D1 in human coronary artery smooth muscle cells ( CASMC ) ... The present study demonstrates that p38 MAPK negatively regulates AngII induced ERK1/2 activity, Rb phosphorylation, cyclin D1 expression, and DNA-synthesis in human CASMC
Shi et al., J Biol Chem 2005 : Furthermore, we show that cyclin D1 and c-myc IRES function is enhanced following exposure to rapamycin and requires both p38 MAPK and RAF/MEK/ERK signaling, as specific inhibitors of these pathways reduce IRES mediated translation and protein levels under conditions of quiescent AKT activity
Yang et al., FASEB J 2006 (MAP Kinase Signaling System) : CSE mediated apoptosis was associated with an increased ERK and p38 MAPK activation , up-regulation of p21 ( Cip/WAK-1 ), and down-regulation of cyclin D1 expression
Lee et al., J Cell Physiol 2006 (MAP Kinase Signaling System) : The dopamine induced decrease in cyclin E, cyclin dependent protein kinase-2 ( CDK-2 ), and cyclin D1 , CDK-4 were blocked by pertussis toxin ( G protein inhibitor ), SQ 22536, neomycin, bisindolylmaleimide I ( PKC inhibitor ), SB 203580 ( p38 MAPK inhibitor ), PD 98059 ( p44/42 inhibitor ), and SP 600125 ( SAPK/JNK inhibitor )
Chung et al., Hum Mol Genet 2006 : Utilizing MCF-7 Tet-Off breast cancer cell lines stably expressing two different nuclear localization defective PTEN mutants, as well as wild-type PTEN and empty vector control cells, we demonstrate that nuclear PTEN down-regulates cyclin D1 transcription and this event is mediated by the down-regulation of MAPK specifically by nuclear localized PTEN
Okabe et al., PloS one 2006 (MAP Kinase Signaling System) : A critical role for FBXW8 and MAPK in cyclin D1 degradation and cancer cell proliferation
Boonyaratanakornkit et al., Steroids 2008 : Progestin induction of CCND1 was observed in cells expressing PR-B but not PR-BDeltaSH3 or PR-A and induction in the presence of PR-B was dramatically reduced in the presence of inhibitors of Src or MAPK
Nieves et al., Biochem Pharmacol 2008 (MAP Kinase Signaling System) : Enantioselective effect of 12 ( S ) -hydroxyeicosatetraenoic acid on 3T6 fibroblast growth through ERK 1/2 and p38 MAPK pathways and cyclin D1 activation
Recchia et al., Int J Biochem Cell Biol 2009 (Lung Neoplasms...) : A cross-talk between the androgen receptor and the epidermal growth factor receptor leads to p38MAPK dependent activation of mTOR and cyclinD1 expression in prostate and lung cancer cells
Lu et al., J Nutr Biochem 2010 (Breast Neoplasms...) : We propose that breast cancer cell proliferation is inhibited by DHA through proteasome dependent degradation of ERalpha, reduced cyclin D1 expression and inhibition of MAPK signaling
Velarde et al., Endocrinology 2009 (Endometriosis) : The MAPK kinase-1/2 inhibitor, U0126, fully restored cAMP down-regulation of CCND1 , but not cAMP up-regulation of IGFBP1, in hESF of women with vs. without endometriosis
Albanese et al., J Biol Chem 1995 : Expression of plasmids encoding either dominant negative MAPK ( p41MAPKi ) or dominant negatives of ETS activation ( Ets-LacZ ), antagonized MAPK dependent induction of cyclin D1 promoter activity
Lavoie et al., J Biol Chem 1996 : We found that inhibition of the p42/p44(MAPK) signaling by expression of dominant negative forms of either mitogen activated protein kinase kinase 1 ( MKK1 ) or p44(MAPK), or by expression of the MAP kinase phosphatase, MKP-1, strongly inhibited expression of a reporter gene driven by the human cyclin D1 promoter as well as the endogenous cyclin D1 protein ... Furthermore, inhibition of p38 ( MAPK ) activity with the specific inhibitor, SB203580, enhanced cyclin D1 transcription and protein level
Ito et al., Hepatology 1998 (Carcinoma, Hepatocellular...) : Furthermore, in 25 of 26 cases of HCC which genomic DNA was available, 22 cases without genomic DNA amplification exhibited positive correlation, not only between protein expression of c-Fos and cyclin D1 , but also between MAPK/ERK activation and cyclin D1 expression ... In conclusion, these findings suggest that MAPK/ERK activation in human HCC may play an important role in multistep hepatocarcinogenesis, especially in the progression of HCC ; at least in part, through cyclin D1 up-regulation primarily induced by MAPK/ERK via c-Fos