Gene interactions and pathways from curated databases and text-mining

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CDK2 — PARP1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Korhonen et al., Neurosci Lett 2005 (Nerve Degeneration) : MK-801 ( NMDA receptor antagonist ) as well as benzamide ( PARP inhibitor ), MDL 28170 ( calpain inhibitor ) and roscovitine ( cyclin dependent kinase inhibitor ) inhibited the glutamate response to the YY1 complexes
Brun et al., Bioorg Med Chem 2005 : They increase inhibitory tyrosine 15 phosphorylation of CDK and induce the cleavage of PARP , a hallmark of apoptosis
Wright et al., Genes Dev 2012 (Breast Neoplasms) : CDK2 dependent activation of PARP-1 is required for hormonal gene regulation in breast cancer cells ... Thus, progestin gene regulation involves a novel signaling pathway that connects CDK2 dependent activation of PARP-1 with histone H1 displacement
Wright et al., Cell cycle (Georgetown, Tex.) 2012 : PARty promoters : Hormone dependent gene regulation requires CDK2 activation of PARP1