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CDKN1A — EPHB2

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Geijsen et al., Blood 1999 : Furthermore, fMLP induced p21rac activation was not inhibited by broad tyrosine kinase inhibitors or specific inhibitors of ERK , p38 mitogen activated protein kinase, Src, or phosphatidylinositol 3-kinases
Bottazzi et al., J Cell Biol 1999 : In contrast to the induction of cyclin D1, the induction of p21 ( cip1 ) is mediated by transient ERK activity
Lee et al., Oncogene 1999 (Breast Neoplasms) : ERK activation by CSF-1 was robust and sustained in MCF-7fms and to a much lesser extent in T-47Dfms. Using pharmacological and transient transfection approaches, we showed that ERK activation was necessary and sufficient for p21 induction in MCF-7fms
Das et al., FEBS Lett 2000 : This implies that a link exists between ERK activation and p21 ( WAF ) and p27 ( kip1 ) induction in the process of terminal differentiation
Sellers et al., Mol Cell Biol 2000 (MAP Kinase Signaling System) : In addition, although all receptors mediated a sustained activation of extracellular signal regulated kinases ( ERK1 and ERK2 ), induction of the tumor suppressor p21 ( cip1 ) was detected only following amplification of ERK and p38 phosphorylation by concomitant bFGF and sst ( 2 ( a ) ) receptor activation
Iglesias et al., Oncogene 2000 (Carcinoma...) : PD098059, a specific inhibitor of MEK, disminishes TGF-beta1 induced p21Cip1 levels in PDV but not in MCA3D cells, suggesting an involvement of Erk in up-regulation of p21Cip1 by TGF-beta1 in PDV cells
Ozaki et al., Infect Immun 2001 (MAP Kinase Signaling System) : These results show that the bacterial fimbriae inhibited apoptosis of THP-1 cells induced under growth factor deprivation via ERK dependent expression of p21
Ranginwale et al., Exp Cell Res 2001 (MAP Kinase Signaling System) : We now directly confirm this prediction by showing that oncogenic p21 induces activating phosphorylation of JNK ( JNK-P ) and of ERK ( MAP kinase ) ( MAPK-P ), whose levels correlate with oocyte maturation
Bang et al., Biochem Biophys Res Commun 2001 : Taken together, our data suggest that VES induces activation of PKC and PKC dependent hypophosphorylation of retinoblastoma protein, which results in induction of apoptosis, and that VES induced early activation of ERK and ERK dependent induction of p21 ( WAF1 ) are not required for apoptosis
Tang et al., J Biol Chem 2002 : Inhibition of ERK activation by PD98059 or U0126 attenuated p21 ( CIP1 ) induction, resulting in partial release of the G(2)/M cell cycle arrest induced by ETOP
Lee et al., Mol Cells 2002 : Expression of p21WAF1 is dependent on the activation of ERK during vitamin E-succinate induced monocytic differentiation ... Inhibition of the ERK activity by PD98059 also diminished the VES induced p21WAF1 protein expression, but did not change the phosphorylation state of the retinoblastoma protein
Lee et al., Cell Growth Differ 2002 : Moreover, p53 and p21 ( Waf ) induction by radiation were higher in PKCdelta overexpressed cells than control cells, and PKCdelta mediated apoptosis was reduced , when radiation induced ERK1/2 activity was inhibited by PD98059
Lai et al., Mol Cell Biol 2002 : We demonstrated that in PMA induced adherent cells, upregulation of p21 ( Cip1/Waf1 ) requires the activation and nuclear translocation of phosphorylated extracellular signal regulated kinase ( phospho-ERK ) ... Finally, we demonstrated that inhibition of ROCK restores nuclear distribution of phospho-ERK and activation of p21 ( Cip1/Waf1 ) expression
Park et al., Br J Pharmacol 2002 (Colorectal Neoplasms) : Extracellular zinc stimulates ERK dependent activation of p21 ( Cip/WAF1 ) and inhibits proliferation of colorectal cancer cells
Zhang et al., Free Radic Biol Med 2003 : PD98059, an inhibitor of ERK , and SB202190, an inhibitor of p38, inhibited vanadate induced cell growth arrest, upregulation of p21 and cdc2, and degradation of cdc25C
Park et al., Am J Physiol Gastrointest Liver Physiol 2003 (Colorectal Neoplasms) : Moreover, this ERK activation and cyclin D1 and p21 ( Cip/WAF1 ) induction were abolished by PD-98059 pretreatment ... The differential regulations of cell growth, ERK activities, and cyclin D1 and p21 ( Cip/WAF1 ) inductions were also observed in serum enriched medium containing higher zinc concentrations
Rahmani et al., Cancer Res 2003 : Enforced expression of doxycycline-inducible p21 ( CIP1 ) or constitutively active MEK1 significantly diminished 17-AAG/SAHA mediated lethality, indicating that interference with ERK activation and p21 ( CIP1 ) induction play important functional roles in the lethal effects of this regimen
Eblen et al., Mol Cell Biol 2004 (MAP Kinase Signaling System) : It was previously shown that Rac-p21 activated kinase (PAK) signaling regulated the physical association of MEK1 with ERK2 through phosphorylation sites in the proline-rich sequence (PRS) of MEK1
Ko et al., Exp Cell Res 2004 (Adenocarcinoma...) : Decreasing phospho-ERK with the pharmacological inhibitors, PD98059 and U0126, markedly suppresses hyperoxia stimulated phospho-p53 ( Ser15 ), p53, and p21 ( CIP1 ), and also restores the hyperoxia reduced kinase activities of cyclin D1/E1-Cdks
Nakajima et al., Biochem Biophys Res Commun 2004 : These results for the first time demonstrate that up-regulation of p21 expression by ERK1/2 and p38 MAP kinase is required for chondrogenesis, and that JNK acts as a suppressor of chondrogenesis by down regulating p21 expression
Chen et al., J Cell Biochem 2004 (Carcinoma, Papillary...) : The induced levels of HO-1 and p21 were significantly reduced by p38 mitogen activated protein kinase ( p38 MAPK ) and extracellular regulated kinase (ERK) inhibitors
Vaqué et al., J Biol Chem 2005 (Leukemia...) : c-Myc antagonized the induction of p21Cip1 mediated by oncogenic H-, K-, and N-Ras and by constitutively activated Raf and ERK2
Park et al., Exp Mol Med 2004 (Colorectal Neoplasms) : However, not all the cells appeared to respond to ERK pathway dependent p21Cip/WAF1 induction
Miura et al., Atherosclerosis 2005 (Atherosclerosis...) : JTT-705 induced the upregulation of p-p21 ( waf1 ), and this effect was blocked by dominant negative Ras ( N17 ), but not by inhibitors of p38 MAPK or ERK
Lee et al., Arch Biochem Biophys 2005 (MAP Kinase Signaling System) : In addition, the transcription factor Sp1 that is involved in the Ras/ERK mediated control of p21WAF1 regulation in VSMC in response to PDGF has now been identified
Huang et al., J Biomed Sci 2006 (Carcinoma, Squamous Cell) : Opposite effect of ERK1/2 and JNK on p53 independent p21WAF1/CIP1 activation involved in the arsenic trioxide induced human epidermoid carcinoma A431 cellular cytotoxicity ... Therefore, we conclude that in A431 cells the ERK1/2 and JNK pathways might differentially contribute to As2O3 induced p21 expression and then due to cellular cytotoxicity
Ciccarelli et al., Molecular cancer 2005 (MAP Kinase Signaling System...) : Furthermore, the TPA mediated post-transcriptional mechanism of p21WAF1 enhanced expression in RD cells is due to activation of the MEK/ERK pathway, as shown by transfections with constitutively active MEK1 or MEK2, which induces p21WAF1 expression, and with ERK1 and ERK2 siRNA, which prevents p21WAF1 expression
Chen et al., Bioorg Med Chem 2006 (Prostatic Neoplasms) : The antiproliferative effect was correlated with ERK activation and p21 ( waf1 ) induction
Wang et al., World J Gastroenterol 2007 (Carcinoma, Hepatocellular...) : During the process, the expression of p21 protein increased , while that of cyclinD1, phospho-ERK1/2 and c-myc decreased
Wu et al., Cancer Lett 2007 (MAP Kinase Signaling System) : Specific blockade of MEK1/MEK2 cascade upstream from ERK1/2 abrogated 1,25D activation of AP-1 and p21 , and subsequent antiproliferative effects, even in the presence of a nuclear VDR
Liu et al., Cell Mol Biol Incl Cyto Enzymol 2006 (Ion Channel Gating) : Therapeutic concentrations of digitalis drugs inhibit the proliferation of breast cancer cells by inducing the interaction of Na+/K+-ATPase with Src/EGFR, activation of ERK1/2 , and the resulting upregulation of cell cycle inhibitor p21Cip1
Yang et al., Biochem J 2008 (Breast Neoplasms) : Heregulin beta1 promotes breast cancer cell proliferation through Rac/ERK dependent induction of cyclin D1 and p21Cip1
Fortino et al., Cancer Invest 2008 (Breast Neoplasms) : In this study, we evaluated the proliferative behavior of PMA treated MCF-7 breast cancer cell and found that : PMA induced growth arrest and inhibited cell death ; PMA activated ERKs, which, in turn, induced p21 ; and inhibitors of ERK ( PD98059 ) and PKC ( GF109203X ) prevented p21 induction and abolished the PMA survival effect ... We conclude that PMA inhibits MCF-7 cell growth and simultaneously stimulates cell survival ; both responses are linked to ERK dependent and p53 independent p21 induction
Liu et al., J Biomed Sci 2008 : Previously, we had demonstrated that opposing effects of ERK1/2 and JNK on p21 expression in response to arsenic trioxide ( As ( 2 ) O ( 3 ) ) are mediated through the Sp1 responsive elements of the p21 promoter in A431 cells
Ho et al., Toxicol Appl Pharmacol 2008 : Inhibition of the ERK phosphorylation plays a role in terbinafine induced p21 up-regulation and DNA synthesis inhibition in human vascular endothelial cells ... Taken together, these data suggest that the decrease of ERK activity plays a role in the TB-induced up-regulation of p21 in HUVEC
Choi et al., Cancer Res 2008 (Glioma) : Our results indicate that ERK and JNK MAPK/Elk-1/Egr-1 signal cascade is required for p53 independent transcriptional activation of p21 ( Waf1/Cip1 ) in response to curcumin in U-87MG human glioblastoma cells
Moosavi et al., Toxicol Appl Pharmacol 2008 : The differentiated cells arrested in G ( 0 ) /G ( 1 ) phase of cell cycle and showed early activation of ERK1/2 pathway ( 3 h ) along with ERK dependent p21 ( Cip/WAF1 ) ( p21 ) up-regulation and expression of p27 ( Kip1 ) and Bcl-2
Ding et al., J Huazhong Univ Sci Technolog Med Sci 2008 (Carcinoma, Adenoid Cystic...) : MTT demonstrated ACC-2 cell proliferation was substantially enhanced by bFGF, immuno-precipitation displayed ERK activity was up-regulated by bFGF, and immuno imprinting also showed p-ERK ( 1/2 ), cyclin D1 expression was greatly enhanced and p21 ( waf/cip1 ) expression was inhibited by bFGF
Park et al., Int J Mol Med 2008 (Breast Neoplasms...) : Overall, the TsA activated ERK pathway plays an important role in cell cycle arrest and apoptosis through the ERK dependent induction of p21 in Ras related human cancer cells
Frémin et al., Hepatology 2009 : We identified this mechanism by showing that this blockage was in part supported by ERK2 dependent p21 expression
Deng et al., Ann Clin Lab Sci 2009 (Cardiomegaly) : Since PNC-2 blocks oncogenic ras-p21 induced activation of JNK and ERK , we further determined whether this peptide blocks activation of these kinases in NE-treated myocytes
Arakawa et al., Biochem Biophys Res Commun 2010 (Melanoma) : These results suggest that IL-1 induced ERK1/2 activation leads to the up-regulation of p21 by inhibiting degradation via ubiquitin independent pathway in human melanoma cells A375
Yuan et al., Clin Exp Metastasis 2010 (Brain Neoplasms...) : ERK activation of p21 activated kinase-1 (Pak1) is critical for medulloblastoma cell migration
Wang et al., Oncol Rep 2010 (Carcinoma, Hepatocellular...) : Immunoblot analysis demonstrated that oridonin treatment increased expression levels of p-JNK, p-p38, p-p53 and p21 , elevated the level of cyclin B1/p-Cdc2 ( Tyr15 ) complex, and inhibited the expression of p-ERK
Besancenot et al., PLoS Biol 2010 : Here, we show that TPO induces cell-cycle arrest in the megakaryocytic UT7-MPL cell line by the activation of the ERK/MAPK pathway, induction of p21CIP transcription, and senescence markers through EGR1 activation
Saito et al., J Exp Med 2010 (Cell Transformation, Neoplastic...) : In nonpolarized epithelial cells, Erk activation results in oncogenic stress, up-regulation of the p21 ( Waf1/Cip1 ) cyclin dependent kinase inhibitor, and induction of senescence
Latini et al., BMC cancer 2011 (Neoplasms, Experimental...) : These responses were accompanied by the up-regulation of the cell cycle inhibitor p21 WAF1 and reduced ERK phosphorylation and E2F1 expression
Xu et al., Clin Exp Pharmacol Physiol 2011 : In addition, TSG suppressed PDGF-BB induced downregulation of p27 and upregulation of p21 , as well as PDGF-BB induced activation of ERK1/2
Lv et al., Marine drugs 2013 (Carcinoma...) : Moreover, asperolide A significantly activated MAP kinases ( ERK1/2, JNK and p38 MAP kinase ) by phosphorylation, and only the inhibition of ERK activation by PD98059 reversed downregulation of G2/M regulatory proteins CDC2, and suppressed upregulation of p21 and p-p53 levels
Hazawa et al., FEBS open bio 2012 : VN attenuated radiation induced expression of p21 , an inhibitor of cell cycle progression, and selectively inhibited Erk- and p38 MAPK dependent p21 induction after radiation exposure through regulation of the activity of GSK-3ß
Izquierdo et al., Eur J Immunol 1994 : The data demonstrate that phorbol ester and HM1R regulation of ERK2 was prevented by the PKC inhibitor, but that the inhibitor had no effect on ERK2 activation induced by expression of a constitutively active ras mutant p21v-Ha-ras
Itoh et al., Proc Natl Acad Sci U S A 1993 : In this cell-free system, the guanosine 5'- [ gamma-thio ] triphosphate- bound form of Ki-ras p21 , but not the GDP bound form, activates endogenous Xenopus MAP kinase as well as recombinant ERK2 in the presence of the cytosol fraction of Xenopus oocytes ... Both factors were necessary for Ki-ras p21 dependent activation of MAP kinase/ERK2
Florio et al., Mol Endocrinol 1999 : The activation of ERK by SSTR1 increased the expression of the cyclin dependent protein kinase inhibitor p21 ( cip1/WAF1 )