Gene interactions and pathways from curated databases and text-mining

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CDKN1A — PRKAR1B

Text-mined interactions from Literome

Rao et al., Exp Cell Res 1999 (Breast Neoplasms) : In the present study we examined the role of cAMP dependent protein kinase (PKA) on p21 and p27 induction in the breast cancer cell line, MDA-MB-157
Lee et al., Oncogene 2000 (Lung Neoplasms) : Furthermore, PKA activators forskolin and dibutyryl-cAMP activated p21WAFI promoter activity and increased p21wAF1 protein level in lung cancer cells ... Taken together, these results demonstrate that Tam activates the p21WAF1 promoter via Sp1 binding sites and suggest that PKA may be involved in the induction of p21wAF1 by Tam in ER-negative lung cancer cells
D'Souza et al., Am J Physiol Cell Physiol 2003 : The increased levels of p53 and p21 observed in eNOS transfected cells were reduced in the presence of the PKA inhibitor ... These data suggest that p21 and p53 play a role in the inhibition of proliferation in eNOS transfected cells and that levels of these two proteins are regulated by PKA
Begum et al., J Biol Chem 2011 (MAP Kinase Signaling System) : We conclude that PDE3A regulates VSMC growth via two complementary pathways, i.e. PKA catalyzed inhibitory phosphorylation of Raf-1 with resulting inhibition of MAPK signaling and PKA/CREB mediated induction of p21 , leading to G0/G1 cell cycle arrest, as well as by increased accumulation of p53, which induces MKP-1, p21, and WIP1, leading to inhibition of G1 to S cell cycle progression