◀ Back to CASP8
CASP8 — CFLAR
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
CASP8
→
CFLAR
(decreases, CFLAR Activity)
Evidence: Figure 3 , Neuronal anti-apoptotic brakes upstream of mitochondria. Black lines represent apoptotic pathways,blue lines represent survival pathways and red lines indicate inhibition or activation (arrows). TNF? (tumour necrosis factor-?)- and FASL (apoptosis antigen-1 (FAS) ligand) mediated death can be suppressed by sequestration by decoy receptors; FASL can bind to DCR3 (decoy receptor 3) or FDR (FAS decoy receptor), or to MET3, a HGF (hepatocyte growth factor) receptor,resulting in no downstr...
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BioCarta hiv-1 nef: negative effector of fas and tnf:
FAS/FADD/DAXX/ASK1/Caspase 8/Caspase 8/FAS L complex (FAS-FADD-DAXX-MAP3K5-CASP8-FASLG)
→
I-FLICE (CFLAR)
(modification, activates)
-
BioCarta fas signaling pathway (cd95):
I-FLICE/RIP2 complex (CFLAR-RIPK2)
→
Caspase 8 (CASP8)
(modification, inhibits)
-
BioCarta fas signaling pathway (cd95):
I-FLICE/RIP2 complex (CFLAR-RIPK2)
→
Caspase 8 (active) (CASP8)
(modification, inhibits)
-
KEGG Chagas disease (American trypanosomiasis):
CFLAR
→
CASP8
(protein-protein, inhibition)
-
NCI Pathway Database TRAIL signaling pathway:
c-FLIP (CFLAR)
→
Caspase 8 (CASP8)
(modification, inhibits)
Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Kischkel et al., Immunity 2000, Ganten et al., Cell Death Differ 2004, Jin et al., Mol Cell Biol 2006, Walczak et al., EMBO J 1997
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database TRAIL signaling pathway:
c-FLIP (CFLAR)
→
Caspase 8 (tetramer) complex (CASP8)
(modification, inhibits)
Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Kischkel et al., Immunity 2000, Ganten et al., Cell Death Differ 2004, Jin et al., Mol Cell Biol 2006, Walczak et al., EMBO J 1997
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database TRAIL signaling pathway:
c-FLIP (CFLAR)
→
Caspase 8 (CASP8)
(modification, inhibits)
Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Kischkel et al., Immunity 2000, Miyazaki et al., Nat Immunol 2001, Ganten et al., Cell Death Differ 2004, Jin et al., Mol Cell Biol 2006, Walczak et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TRAIL signaling pathway:
c-FLIP (CFLAR)
→
Caspase 8 (tetramer) complex (CASP8)
(modification, inhibits)
Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Kischkel et al., Immunity 2000, Miyazaki et al., Nat Immunol 2001, Ganten et al., Cell Death Differ 2004, Jin et al., Mol Cell Biol 2006, Walczak et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
cIAP1-2 (BIRC2/BIRC3)
→
FASLG/FAS (trimer)/FADD/FADD/CASP8 p43/c-FLIP p43 complex (FAS-FASLG-FADD-CASP8-CFLAR)
(modification, inhibits)
Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
Caspase 8 (CASP8)
→
c-FLIP (CFLAR)
(modification, collaborate)
Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
Caspase 8 (CASP8)
→
FASLG/FAS (trimer)/FADD/FADD/CFLIP complex (FAS-FASLG-FADD-CFLAR)
(modification, collaborate)
Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
Caspase 8 (CASP8)
→
FASLG/FAS (trimer)/FADD/FADD/CASP8 p43/c-FLIP p43 complex (FAS-FASLG-FADD-CASP8-CFLAR)
(modification, collaborate)
Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
Caspase 8 (CASP8)
→
c-FLIP p12 (CFLAR)
(modification, collaborate)
Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
FASLG/FAS (trimer)/FADD/FADD/CASP8/CASP8 complex (FAS-FASLG-FADD-CASP8)
→
c-FLIP (CFLAR)
(modification, collaborate)
Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
FASLG/FAS (trimer)/FADD/FADD/CASP8/CASP8 complex (FAS-FASLG-FADD-CASP8)
→
FASLG/FAS (trimer)/FADD/FADD/CFLIP complex (FAS-FASLG-FADD-CFLAR)
(modification, collaborate)
Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
FASLG/FAS (trimer)/FADD/FADD/CASP8/CASP8 complex (FAS-FASLG-FADD-CASP8)
→
FASLG/FAS (trimer)/FADD/FADD/CASP8 p43/c-FLIP p43 complex (FAS-FASLG-FADD-CASP8-CFLAR)
(modification, collaborate)
Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
FASLG/FAS (trimer)/FADD/FADD/CASP8/CASP8 complex (FAS-FASLG-FADD-CASP8)
→
c-FLIP p12 (CFLAR)
(modification, collaborate)
Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
c-FLIP (CFLAR)
→
Caspase 8 p10 (CASP8)
(modification, collaborate)
Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
c-FLIP (CFLAR)
→
FASLG/FAS (trimer)/FADD/FADD/CASP8 p43/c-FLIP p43 complex (FAS-FASLG-FADD-CASP8-CFLAR)
(modification, collaborate)
Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
Caspase 8 p10 (CASP8)
→
FASLG/FAS (trimer)/FADD/FADD/CFLIP complex (FAS-FASLG-FADD-CFLAR)
(modification, collaborate)
Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
Caspase 8 p10 (CASP8)
→
FASLG/FAS (trimer)/FADD/FADD/CASP8 p43/c-FLIP p43 complex (FAS-FASLG-FADD-CASP8-CFLAR)
(modification, collaborate)
Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
Caspase 8 p10 (CASP8)
→
c-FLIP p12 (CFLAR)
(modification, collaborate)
Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD)
→
FASLG/FAS (trimer)/FADD/FADD/CASP8 p43/c-FLIP p43 complex (FAS-FASLG-FADD-CASP8-CFLAR)
(modification, collaborate)
Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
FASLG/FAS (trimer)/FADD/FADD/CFLIP complex (FAS-FASLG-FADD-CFLAR)
→
FASLG/FAS (trimer)/FADD/FADD/CASP8 p43/c-FLIP p43 complex (FAS-FASLG-FADD-CASP8-CFLAR)
(modification, collaborate)
Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
FASLG/FAS (trimer)/FADD/FADD/CASP8 p43/c-FLIP p43 complex (FAS-FASLG-FADD-CASP8-CFLAR)
→
c-FLIP p12 (CFLAR)
(modification, collaborate)
Yeh et al., Immunity 2000, Krueger et al., J Biol Chem 2001, Algeciras-Schimnich et al., Mol Cell Biol 2002, Chang et al., EMBO J 2002, Geserick et al., J Cell Biol 2009, Muzio et al., Cell 1996, Medema et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
c-FLIPS (CFLAR)
→
Caspase 8 (CASP8)
(modification, collaborate)
Krueger et al., J Biol Chem 2001, Chang et al., EMBO J 2002
Evidence: assay
-
NCI Pathway Database FAS (CD95) signaling pathway:
c-FLIPS (CFLAR)
→
FASLG/FAS (trimer)/FADD/FADD/CASP8/c-FLIPS complex (FAS-FASLG-FADD-CASP8-CFLAR)
(modification, collaborate)
Krueger et al., J Biol Chem 2001, Chang et al., EMBO J 2002
Evidence: assay
-
NCI Pathway Database FAS (CD95) signaling pathway:
Caspase 8 (CASP8)
→
FASLG/FAS (trimer)/FADD/FADD/CASP8/c-FLIPS complex (FAS-FASLG-FADD-CASP8-CFLAR)
(modification, collaborate)
Krueger et al., J Biol Chem 2001, Chang et al., EMBO J 2002
Evidence: assay
-
NCI Pathway Database FAS (CD95) signaling pathway:
FASLG/FAS (trimer)/FADD/FADD/CASP8/c-FLIPS complex (FAS-FASLG-FADD-CASP8-CFLAR)
→
FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD)
(modification, collaborate)
Krueger et al., J Biol Chem 2001, Chang et al., EMBO J 2002
Evidence: assay
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
c-FLIP (CFLAR)
→
FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8/FASLG complex (FASLG-CASP8-MAP3K5-FAS-DAXX-FADD)
(modification, inhibits)
Medema et al., EMBO J 1997
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
c-FLIP (CFLAR)
→
Caspase 8 (4 units) complex (CASP8)
(modification, inhibits)
Medema et al., EMBO J 1997
-
Reactome Reaction:
CASP8
→
CFLAR
(reaction)
Siegmund et al., J Biol Chem 2001, Micheau et al., Mol Cell Biol 2001*, Micheau et al., J Biol Chem 2002*, Donepudi et al., Mol Cell 2003, Micheau et al., Cell 2003, Kreuz et al., J Cell Biol 2004, Sharp et al., J Biol Chem 2005*, Kim et al., Journal of molecular signaling 2008*, Rushworth et al., Cell cycle (Georgetown, Tex.) 2008*, Seal et al., Exp Hematol 2008*, Vittori et al., Cell Biol Int 2010*, Fricker et al., J Cell Biol 2010*, Yerbes et al., Biochim Biophys Acta 2011*, Pop et al., Biochem J 2011*, Scaffidi et al., J Biol Chem 1999
-
Reactome Reaction:
CASP8
→
CFLAR
(direct_complex)
Siegmund et al., J Biol Chem 2001, Micheau et al., J Biol Chem 2002*, Donepudi et al., Mol Cell 2003, Micheau et al., Cell 2003, Kreuz et al., J Cell Biol 2004, Sharp et al., J Biol Chem 2005*, Rushworth et al., Cell cycle (Georgetown, Tex.) 2008*, Seal et al., Exp Hematol 2008*, Vittori et al., Cell Biol Int 2010*, Fricker et al., J Cell Biol 2010*, Yerbes et al., Biochim Biophys Acta 2011*, Scaffidi et al., J Biol Chem 1999
-
Reactome Reaction:
CASP8
→
CFLAR
(indirect_complex)
Micheau et al., Mol Cell Biol 2001*, Kim et al., Journal of molecular signaling 2008*, Pop et al., Biochem J 2011*, Scaffidi et al., J Biol Chem 1999
-
WikiPathways Nanomaterial induced apoptosis:
CFLAR
→
CASP8
(mim-inhibition)
-
WikiPathways Apoptosis Modulation and Signaling:
CFLAR
→
CASP8
(inhibition)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind_translation Interaction:
CFLAR
—
CASP8
(affinity chromatography technology)
Han et al., Proc Natl Acad Sci U S A 1997*
-
IRef Bind_translation Interaction:
CFLAR
—
CASP8
(two hybrid)
Han et al., Proc Natl Acad Sci U S A 1997*
-
IRef Bind_translation Interaction:
CFLAR
—
CASP8
(coimmunoprecipitation)
Han et al., Proc Natl Acad Sci U S A 1997*
-
IRef Biogrid Interaction:
CASP8
—
CFLAR
(physical association, affinity chromatography technology)
Kerr et al., Cell Death Differ 2012*
-
IRef Biogrid Interaction:
CASP8
—
CFLAR
(physical association, affinity chromatography technology)
Micheau et al., Cell 2003
-
IRef Biogrid Interaction:
CASP8
—
CFLAR
(physical association, affinity chromatography technology)
Sinha et al., J Biol Chem 2004*
-
IRef Biogrid Interaction:
CASP8
—
CFLAR
(physical association, affinity chromatography technology)
Rébé et al., Blood 2007
-
IRef Biogrid Interaction:
CASP8
—
CFLAR
(physical association, affinity chromatography technology)
Lee et al., Nature communications 2012
-
IRef Biogrid Interaction:
CASP8
—
CFLAR
(physical association, affinity chromatography technology)
Micheau et al., J Biol Chem 2002*
-
IRef Biogrid Interaction:
CASP8
—
CFLAR
(direct interaction, two hybrid)
Goltsev et al., J Biol Chem 1997*
-
IRef Biogrid Interaction:
CASP8
—
CFLAR
(physical association, affinity chromatography technology)
Shu et al., Immunity 1997*
-
IRef Biogrid Interaction:
CASP8
—
CFLAR
(direct interaction, two hybrid)
Srinivasula et al., J Biol Chem 1997*
-
IRef Biogrid Interaction:
CASP8
—
CFLAR
(direct interaction, pull down)
Srinivasula et al., J Biol Chem 1997*
-
IRef Biogrid Interaction:
CASP8
—
CFLAR
(physical association, affinity chromatography technology)
Srinivasula et al., J Biol Chem 1997*
-
IRef Biogrid Interaction:
CASP8
—
CFLAR
(physical association, affinity chromatography technology)
Han et al., Proc Natl Acad Sci U S A 1997*
-
IRef Biogrid Interaction:
CASP8
—
CFLAR
(direct interaction, pull down)
Han et al., Proc Natl Acad Sci U S A 1997*
-
IRef Biogrid Interaction:
CASP8
—
CFLAR
(direct interaction, two hybrid)
Han et al., Proc Natl Acad Sci U S A 1997*
-
IRef Biogrid Interaction:
CASP8
—
CFLAR
(physical association, affinity chromatography technology)
Roth et al., J Biol Chem 2002*
-
IRef Biogrid Interaction:
CASP8
—
CFLAR
(physical association, affinity chromatography technology)
Zhang et al., Am J Physiol Cell Physiol 2009*
-
IRef Biogrid Interaction:
CASP8
—
CFLAR
(physical association, affinity chromatography technology)
Tenev et al., Mol Cell 2011
-
IRef Biogrid Interaction:
CASP8
—
CFLAR
(direct interaction, enzymatic study)
Kaunisto et al., Cell Death Differ 2009*
-
MIPS CORUM MRIT complex:
MRIT complex complex (BCL2L1-CASP8-CFLAR)
Han et al., Proc Natl Acad Sci U S A 1997*
-
MIPS CORUM Death induced signaling complex II (FADD, CASP8, CFLAR), cytosolic, CD95L induced:
Death induced signaling complex II (FADD, CASP8, CFLAR), cytosolic, CD95L induced complex (CASP8-CFLAR-FADD)
Lavrik et al., J Biol Chem 2008
-
MIPS CORUM Death induced signaling complex DISC (FAS, FADD, CASP8, CFLAR), membrane-associated, CD95L induced:
Death induced signaling complex DISC (FAS, FADD, CASP8, CFLAR), membrane-associated, CD95L induced complex (CASP8-CFLAR-FADD-FAS)
Lavrik et al., J Biol Chem 2008
-
IRef Corum Interaction:
Complex of BCL2L1-CFLAR-CFLAR-CFLAR-BCL2L1-BCL2L1-CASP8-CASP8-CASP8
(association, two hybrid)
Han et al., Proc Natl Acad Sci U S A 1997*
-
IRef Hprd Interaction:
CFLAR
—
CASP8
(in vivo)
Niikura et al., J Biochem 2002*, Micheau et al., J Biol Chem 2002*, Feig et al., EMBO J 2007*, Shu et al., Immunity 1997*, Goltsev et al., J Biol Chem 1997*, Inohara et al., Proc Natl Acad Sci U S A 1997*
-
IRef Hprd Interaction:
CFLAR
—
CASP8
(in vitro)
Niikura et al., J Biochem 2002*, Micheau et al., J Biol Chem 2002*, Feig et al., EMBO J 2007*, Shu et al., Immunity 1997*, Goltsev et al., J Biol Chem 1997*, Inohara et al., Proc Natl Acad Sci U S A 1997*
-
IRef Hprd Interaction:
Complex of 17 proteins
MacFarlane et al., J Biol Chem 1997
-
IRef Hprd Interaction:
Complex of 17 proteins
MacFarlane et al., J Biol Chem 1997
-
IRef Hprd Interaction:
Complex of 17 proteins
MacFarlane et al., J Biol Chem 1997
-
IRef Innatedb Interaction:
CASP8
—
CFLAR
(unknown, -)
Rébé et al., Blood 2007
-
IRef Innatedb Interaction:
CASP8
—
CFLAR
(unknown, -)
Niikura et al., J Biochem 2002*
-
IRef Innatedb Interaction:
CASP8
—
CFLAR
(unknown, -)
Inohara et al., Proc Natl Acad Sci U S A 1997*
-
IRef Innatedb Interaction:
CASP8
—
CFLAR
(unknown, -)
Kataoka et al., Mol Cell Biol 2004*
-
IRef Innatedb Interaction:
Complex of CASP8-FADD-CFLAR-CASP10
(unknown, -)
Estornes et al., Cell Death Differ 2012
-
IRef Innatedb Interaction:
Complex of CFLAR-FADD-CASP8-CASP8-FADD-CFLAR
(unknown, -)
Estornes et al., Cell Death Differ 2012
-
IRef Innatedb Interaction:
Complex of CASP8-CASP3-CFLAR
(unknown, -)
Shu et al., Immunity 1997*
-
IRef Intact Interaction:
CASP8
—
CFLAR
(physical association, anti bait coimmunoprecipitation)
Feig et al., EMBO J 2007*
-
IRef Intact Interaction:
Complex of 21 proteins
(association, anti bait coimmunoprecipitation)
Jin et al., Cell 2009
-
IRef Intact Interaction:
Complex of CASP8-RIPK1-TNFRSF10A-TNFRSF10B-FADD-CFLAR
(association, anti bait coimmunoprecipitation)
Rébé et al., Blood 2007
-
IRef Intact Interaction:
Complex of FADD-FAS-CFLAR-CASP8
(association, anti bait coimmunoprecipitation)
Tao et al., Blood 2011
-
IRef Intact Interaction:
Complex of TRAF2-RIPK1-TRADD-FADD-CASP8-CFLAR
(association, anti bait coimmunoprecipitation)
Rébé et al., Blood 2007
-
IRef Intact Interaction:
Complex of 17 proteins
(association, anti bait coimmunoprecipitation)
Rébé et al., Blood 2007
-
IRef Intact Interaction:
Complex of 11 proteins
(association, anti tag coimmunoprecipitation)
Unterkircher et al., Clin Cancer Res 2011*
-
IRef Intact Interaction:
Complex of CFLAR-FAS-CASP8-CFLAR-FAS-CASP8
(association, anti bait coimmunoprecipitation)
Shatnyeva et al., PloS one 2011*
-
IRef Intact Interaction:
Complex of 43 proteins
(association, anti tag coimmunoprecipitation)
Bangert et al., Oncogene 2012*
-
IRef Intact Interaction:
Complex of TNFRSF10B-TNFSF10-CFLAR-CASP8-FADD-CASP10
(association, pull down)
Horova et al., FEBS J 2013
-
IRef Intact Interaction:
Complex of TRAF2-TRAF1-TRADD-FADD-CASP8-CFLAR-BIRC2-RIPK1
(association, anti bait coimmunoprecipitation)
Micheau et al., Cell 2003
-
IRef Intact Interaction:
Complex of CASP8-CASP10-CFLAR-TRADD-TRAF2-RIPK1-FADD
(association, anti bait coimmunoprecipitation)
Micheau et al., Cell 2003
-
IRef Intact Interaction:
Complex of 17 proteins
(association, anti bait coimmunoprecipitation)
Tao et al., Blood 2011
-
IRef Intact Interaction:
Complex of CASP10-CFLAR-CASP8
(association, anti tag coimmunoprecipitation)
Micheau et al., Cell 2003
-
IRef Ophid Interaction:
CASP8
—
CFLAR
(aggregation, confirmational text mining)
Micheau et al., J Biol Chem 2002*
-
IRef Ophid Interaction:
CASP8
—
CFLAR
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
-
IRef Ophid Interaction:
CASP8
—
CFLAR
(aggregation, confirmational text mining)
Inohara et al., Proc Natl Acad Sci U S A 1997*
-
STRING interaction:
CFLAR
—
CASP8
(interaction, mapped from grid reactome kegg_pathways mint intact)
-
STRING interaction:
CFLAR
—
CASP8
(interaction, mapped from grid reactome kegg_pathways mint intact)
-
STRING interaction:
CASP8
—
CFLAR
(interaction, mapped from kegg_pathways)
-
STRING interaction:
CASP8
—
CFLAR
(interaction, mapped from kegg_pathways)
Text-mined interactions from Literome
Matta et al., Cancer Biol Ther 2002
(Neoplasms) :
MRITalpha1/cFLIP ( L ) expression is decreased during drug induced apoptosis and exogenous expression of MRITalpha1/cFLIP ( L )
delays the activation of
caspase-8 and -3 during drug- induced apoptosis
Madge et al., J Biol Chem 2003
:
Cycloheximide but not LY294002 decreases expression of
c-FLIP ( cellular FLICE inhibitory protein ), an
inhibitor of
caspase-8 activation
Tai et al., Cell Death Differ 2004
:
Instead, suppression of T-cell activation in c-FLIP-transgenic T cells could be a combinatory effect of
FADD/caspase-8 dependent signals and
c-FLIP-specific activities
Chen et al., Biochem Biophys Res Commun 2003
:
In addition, angiostatin also activated the Fas mediated apoptotic pathway in part via up-regulation of FasL mRNA, down-regulation of
c-Flip , and
activation of
caspase 3
Vier et al., Mol Immunol 2004
:
As a
consequence of
caspase-activation ,
c-FLIP-levels in the cytosol decreased
Hasegawa et al., J Biol Chem 2005
(Inflammation) :
ASC mediated NF-kappaB activation leading to interleukin-8 production requires
caspase-8 and is
inhibited by
CLARP ... This response required
caspase-8 , and was
suppressed by
CLARP/FLIP , an inhibitor of caspase-8
Du et al., Kidney Int 2005
:
Consistent with this, IL-2 but not IFN-gamma was found to decrease mRNA and protein expression of
c-FLIP , an endogenous
caspase-8 inhibitor in murine TECs ... Overexpression of
c-FLIP in TECs ( CS3.7-FLIP )
blocked apoptosis and
caspase-8 activation with both IFN-gamma and IL-2
Longley et al., Oncogene 2006
(Colorectal Neoplasms) :
c-FLIP inhibits
caspase 8 activation and apoptosis mediated by death receptors such as Fas and DR5
Chang et al., Cell 2006
(Liver Failure, Acute) :
Here we show that TNFalpha mediated JNK activation accelerates turnover of the NF-kappaB induced antiapoptotic protein
c-FLIP , an
inhibitor of
caspase-8
Saito et al., J Virol 2006
:
A decrease in endogenous
c-FLIP by specific small interfering RNA
induced TNF-alpha mediated apoptotic cell death and
caspase-8 activation
Huber et al., Immunology 2006
(Coxsackievirus Infections...) :
c-FLIP also heterodimerizes with and
activates caspase-8 , resulting in increased death of T cells and a selection of a T helper 2 cytokine profile
da Silva Correia et al., J Biol Chem 2007
:
Furthermore, overexpression of
CLARP , a specific
caspase 8
inhibitor , completely blocked cleavage of CSN6
Wang et al., Cell Signal 2007
(Pancreatic Neoplasms) :
These results indicate the
role of
c-FLIP and RIP in
caspase-8 inhibition and thus TRAIL resistance
Dash et al., Exp Cell Res 2007
:
Inhibition of
cFLIP recruitment to the DISC
leads to increased activation of
caspase 8 and subsequently to apoptosis
Hinshaw-Makepeace et al., Eur J Immunol 2008
:
Here we show that, in contrast to c-FLIP ( L ),
c-FLIP ( S )
inhibits activation of
caspase-8 in T cells, and consequently reduces recruitment of MALT1 and Bcl-10 to the active caspase complex
Roy et al., Proc Natl Acad Sci U S A 2008
:
This molecular role for caspase-12 appears to be akin to the
role of
cFLIP in regulating
caspase-8 in the extrinsic cell death pathway ; however, unlike cFLIP/Usurpin, we demonstrate here that caspase-12 is catalytically competent
Wang et al., Cell 2008
:
Moreover, Smac mimetic induced
caspase-8 activation is not
blocked by endogenous
c-FLIP
Luo et al., Cancer Lett 2008
:
c-FLIP inhibits
caspase-8 activation and cell apoptosis mediated by death receptors
Kim et al., J Cell Biochem 2008
(Kidney Neoplasms) :
cFLIP inhibits
caspase 8 recruitment and processing at the death inducing signaling complex ( DISC ), which is known to inhibits apoptosis mediated by death receptors such as Fas and death receptor 5 (DR5) as well as apoptosis mediated by anticancer therapeutic drugs
Ivanov et al., Cancer Res 2009
(Melanoma) :
Pretreatment of several melanoma lines just before gamma-irradiation with the inhibitor of ATM kinase KU-55933 suppressed p53 and nuclear factor-kappaB (NF-kappaB) activation but notably increased radiation induced DR5 surface expression, down-regulated
cFLIP (
caspase-8 inhibitor ) levels, and substantially enhanced exogenous TRAIL induced apoptosis
Klapproth et al., Blood 2009
(Burkitt Lymphoma...) :
NF-kappaB up-regulates Fas and predisposes to Fas induced cell death, which is
caspase-8 mediated and can be
prevented by
CFLAR overexpression
Eeva et al., Scand J Immunol 2009
:
Fas induced apoptosis was dependent on the caspase-8 activation, since the overexpression of
c-FLIP ( long ), a natural
inhibitor of
caspase-8 activation, blocked apoptosis induced by Fas
Tiwary et al., PloS one 2010
:
Knockdown studies using siRNAs to TRAIL, DR5, JNK and CHOP as well as chemical inhibitors of ER stress and caspase-8 showed that : i ) alpha-TEA activation of DR5/caspase-8 induces an ER stress mediated JNK/CHOP/DR5 positive amplification loop ; ii ) alpha-TEA downregulation of c-FLIP ( L ) protein levels is mediated by JNK/CHOP/DR5 loop via a JNK dependent Itch E3 ligase ubiquitination that further serves to enhance the JNK/CHOP/DR5 amplification loop by preventing
c-FLIP 's
inhibition of
caspase-8 ; and ( iii ) alpha-TEA downregulation of Bcl-2 is mediated by the ER stress dependent JNK/CHOP/DR5 signaling
Liu et al., World J Gastroenterol 2011
(Stomach Neoplasms) :
In vivo, LY294002 inhibited oxaliplatin induced activation of Akt and NF?B, and increased oxaliplatin induced expression of FasL, inhibition of
c-FLIP ( S ), and
activation of
caspase-8 , Bid, and caspase-3
Choi et al., Chem Biol Interact 2011
(Carcinoma, Renal Cell...) :
Cafestol induced apoptosis is associated with the reduction of mitochondrial membrane potential ( MMP ),
activation of
caspase 3, cytochrome c release, and down-regulation of anti-apoptotic proteins ( Bcl-2, Bcl-xL, Mcl-1 and
cFLIP )
Chen et al., J Leukoc Biol 2011
:
Furthermore, tmTNF-a led to
activation of
caspase-8 by dissociation of cFLIP from TNFR2 and inhibition of the
cFLIP expression
Bangert et al., Oncogene 2012
(Glioblastoma) :
This leads to decreased recruitment of cFLIP ( L ) and
cFLIP ( S ) and increased
activation of
caspase-8 to the TRAIL death inducing signaling complex, resulting in enhanced cleavage of caspase-8, -9 and -3 and caspase dependent apoptosis
Shi et al., Bioinformatics 2013
:
cFLIP , an
inhibitor of
caspase-8 activation, was up-regulated briefly after 30 min of LY30 treatment, followed by a significant down-regulation over prolonged exposure
Scaffidi et al., J Biol Chem 1999
:
In stably transfected BJAB cells,
c-FLIP blocks
caspase-8 activation at the DISC and thereby inhibits CD95 mediated apoptosis