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CCND1 — CHUK
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Albanese et al., Mol Biol Cell 2003
:
PI3K dependent induction of
cyclin D1 was
blocked by inhibitors of
PI3K/Akt/IkappaB/IKKalpha or beta-catenin signaling
Kwak et al., J Biol Chem 2005
:
Analysis on cyclin D1 mutants demonstrated that
IKKalpha phosphorylates cyclin D1 at Thr286. Reconstitution of IKKalpha in knockout cells leads to nuclear export and
increased degradation of
cyclin D1
Demicco et al., Mol Cell Biol 2005
(Breast Neoplasms...) :
Constitutively active
IKKalpha induced p52, RelB, and
cyclin D1 in untransformed mammary epithelial cells
Cao et al., Proc Natl Acad Sci U S A 2007
(Breast Neoplasms...) :
Ikkalpha ( AA/AA ) `` knockin '' mice in which activation of IkappaB kinase alpha (IKKalpha) is prevented by replacement of activation loop serines with alanines exhibit delayed mammary gland growth during pregnancy, because
IKKalpha activity is
required for
cyclin D1 induction and proliferation of lobuloalveolar epithelial cells
Wei et al., J Biol Chem 2008
(Prostatic Neoplasms) :
Of several kinases examined, inhibition of
IkappaB kinase alpha blocked STG28 mediated cytoplasmic sequestration and degradation of
cyclin D1
Ouyang et al., J Cell Physiol 2009
:
Soluble and insoluble nickel compounds exert a differential inhibitory effect on cell growth through
IKKalpha dependent
cyclin D1 down-regulation ... Moreover, the soluble nickel induced
cyclin D1 degradation is dependent on its Thr286 residue and
requires IKKalpha , but not HIF-1alpha, which are both reported to be involved in cyclin D1 down-regulation ... Taken together, we demonstrate that soluble, but not insoluble nickel compound, is able to cause
cyclin D1 degradation and a cell growth arrest in an
IKKalpha dependent manner