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McPhee et al., FEBS Lett 2000
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Challenge of Rat1 cells with rolipram alone was able to elicit the phosphorylation of CREB but not activation of either Rap1A or Rap1B
Zanassi et al., J Biol Chem 2001
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These results suggest that, in striatal neurons, intracellular Ca ( 2+ ) release, Rap1 , and ERK pathway play a crucial role in the PKA induced CREB phosphorylation and CREB dependent transcription