Gene interactions and pathways from curated databases and text-mining

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ATF4 — CREB5

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Schinelli et al., J Neurosci 2001 : By using selective protein kinase inhibitors and expression of dominant negative Rap1 protein, we also found that the Rap1/PKC/ERK dependent pathway induces the phosphorylation of activating transcription factor-1 , CREB, and Elk-1, whereas the p38MAPK dependent pathway only causes CREB phosphorylation
Kajimura et al., J Exp Med 2011 (Bone Resorption) : We show that the sympathetic tone signals in the osteoblasts to inhibit CREB ( cAMP-responsive element binding protein ) phosphorylation and thus decrease osteoblast proliferation and to promote ATF4 phosphorylation and thus increase RANKL ( receptor activator of NF-?B ligand ) expression, which then stimulates osteoclast differentiation