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CX3CR1 — IL15
Text-mined interactions from Literome
Barlic et al., Blood 2003
:
IL-15 and IL-2 oppositely
regulate expression of the chemokine receptor
CX3CR1 ... In contrast, we found that in primary mouse bone marrow derived NK cells
IL-15 specifically inhibited CX3CR1 protein and mRNA accumulation, whereas the related cytokine IL-2 did not inhibit but instead
increased CX3CR1 expression ... These data also suggest that
IL-15 inhibition of
CX3CR1 may subvert potential cell immunotherapy strategies in which IL-15 is used to expand NK cell populations in vivo or ex vivo
Barlic et al., J Biol Chem 2004
:
Interleukin (IL)-15 and IL-2 reciprocally
regulate expression of the chemokine receptor
CX3CR1 through selective NFAT1- and NFAT2 dependent mechanisms ... We have recently reported that
interleukin (IL)-15 and IL-2, which signal through IL-2Rbetagamma, oppositely
regulate expression of the proinflammatory chemokine receptor
CX3CR1 ... The
effects of
IL-15 and IL-2 on both
CX3CR1 reporter activity and endogenous CX3CR1 transcription in PBMCs were abolished by the NFAT inhibitors cyclosporin A and VIVIT
Sechler et al., Cell Immunol 2004
:
Recent reports indicate that
IL-15 , which is essential for development and survival of NK cells, may negatively
regulate CX3CR1 expression, however, the effects of the cytokine on human NK cell CX3CR1 expression and function have not been fully delineated