Gene interactions and pathways from curated databases and text-mining

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CX3CR1 — IL15

Text-mined interactions from Literome

Barlic et al., Blood 2003 : IL-15 and IL-2 oppositely regulate expression of the chemokine receptor CX3CR1 ... In contrast, we found that in primary mouse bone marrow derived NK cells IL-15 specifically inhibited CX3CR1 protein and mRNA accumulation, whereas the related cytokine IL-2 did not inhibit but instead increased CX3CR1 expression ... These data also suggest that IL-15 inhibition of CX3CR1 may subvert potential cell immunotherapy strategies in which IL-15 is used to expand NK cell populations in vivo or ex vivo
Barlic et al., J Biol Chem 2004 : Interleukin (IL)-15 and IL-2 reciprocally regulate expression of the chemokine receptor CX3CR1 through selective NFAT1- and NFAT2 dependent mechanisms ... We have recently reported that interleukin (IL)-15 and IL-2, which signal through IL-2Rbetagamma, oppositely regulate expression of the proinflammatory chemokine receptor CX3CR1 ... The effects of IL-15 and IL-2 on both CX3CR1 reporter activity and endogenous CX3CR1 transcription in PBMCs were abolished by the NFAT inhibitors cyclosporin A and VIVIT
Sechler et al., Cell Immunol 2004 : Recent reports indicate that IL-15 , which is essential for development and survival of NK cells, may negatively regulate CX3CR1 expression, however, the effects of the cytokine on human NK cell CX3CR1 expression and function have not been fully delineated