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DISC2 — EGFR

Text-mined interactions from Literome

Reinehr et al., FASEB J 2003 : Inhibition of EGFR tyrosine kinase activity prevented CD95 tyrosine phosphorylation and DISC formation but not hyperosmolarity induced EGFR phosphorylation and EGFR association with CD95
Eberle et al., Hepatology 2005 : Inhibition of EGFR tyrosine kinase activity by AG1478 and cyclic adenosine monophosphate had no effect on hyperosmotic CD95-EGFR association in the cytosol but prevented CD95 tyrosine phosphorylation, targeting of the protein complex to the plasma membrane, and formation of the death inducing signaling complex ( DISC )
Xu et al., Eur J Cancer 2012 (Stomach Neoplasms) : The contribution of DISC formation and the inhibition of EGFR signal triggered in lipid rafts are both essential for increasing the sensitivity of gastric cancer cells to TRAIL