Gene interactions and pathways from curated databases and text-mining

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CASP2 — E2F1

Text-mined interactions from Literome

Lee et al., Mol Cells 2002 : After UV-irradiation the level of E2F1 in E7-expressing astrocytes was higher than E6-, LXSN- or mock infected cells, and caspase-3 was activated to a greater extent
Duxbury et al., Clin Cancer Res 2004 (Adenocarcinoma...) : PP2 augmented gemcitabine induced caspase mediated apoptosis, suppressed RRM2 expression, and decreased activity of the RRM2 regulating transcription factor E2F1 in PANC1 ( GemRes )
Afshar et al., Cancer Res 2006 (Glioma) : In a system of inducible E2F1 activity, E2F1 activated caspase-8 and, accordingly, decreased cellular viability, effects that were abolished by caspase-8 siRNA ... In a system of inducible E2F1 activity, E2F1 activated caspase-8 and, accordingly, decreased cellular viability, effects that were abolished by caspase-8 siRNA