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EIF4G3 — INS
Text-mined interactions from Literome
Wang et al., Am J Physiol Heart Circ Physiol 2000
:
Concomitant with this,
insulin increased the binding of eIF4E to
eIF4G
O'Connor et al., Am J Physiol Endocrinol Metab 2003
:
Both
insulin and amino acids increased the phosphorylation of ribosomal protein S6 kinase ( S6K1 ) and the eIF4E binding protein ( 4E-BP1 ), decreased the binding of 4E-BP1 to eIF4E,
increased eIF4E binding to
eIF4G , and increased fractional protein synthesis rates but did not affect eIF2B activity
Williamson et al., Am J Physiol Endocrinol Metab 2005
:
This appeared to be due to an attenuation of
insulin stimulated
eIF4E.eIF4G association, because other stimulatory effects of INS, e.g., phosphorylation of ERK1/2, 4E-BP1, S6K1, eIF4G, and eIF4E and eIF4E.4E-BP1 association, were unaffected
Suryawan et al., Am J Physiol Endocrinol Metab 2007
:
Both
INS and AA decreased the binding of 4E-BP1 to eIF4E and
increased eIF4E binding to
eIF4G ; these effects were greater in 6-day-old than in 26-day-old pigs
Kimball et al., Am J Physiol 1997
:
However, the
insulin induced association of eIF-4E and
eIF-4G was not due to increased net phosphorylation of eIF-4E because insulin decreased the amount present in the phosphorylated form from 86 to 59 % of total eIF-4E