Gene interactions and pathways from curated databases and text-mining

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EIF4G3 — MTOR

Text-mined interactions from Literome

Vary et al., Alcohol Clin Exp Res 2008 : Furthermore, the data suggest that protein synthesis in rats fed a diet containing ethanol is limited by mTOR dependent reduction in phosphorylation of S6K1 ( Thr ( 389 ) ) and eIF4G ( Ser ( 1108 ) ) secondary to reduced phosphorylation of mTOR ( Ser ( 2448 ) )
Harris et al., EMBO J 2006 : mTOR dependent stimulation of the association of eIF4G and eIF3 by insulin ... Here, we present evidence that mTOR interacts directly with eIF3 and that mTOR controls the association of eIF3 and eIF4G ... This novel effect was blocked by rapamycin and other inhibitors of mTOR , and it required neither eIF4E binding to eIF4G nor eIF3 binding to the 40S ribosomal subunit