Gene interactions and pathways from curated databases and text-mining

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EYA2 — MAPK4

Text-mined interactions from Literome

Silver et al., Mol Cell Biol 2003 : Our data suggest that EYA requires homo- and heterotypic interactions and RAS/MAPK signaling responsiveness to ensure context-appropriate RD gene network activity
Jusiak et al., PloS one 2012 : Ectopic eye induction assays using cDNA transgenes have suggested that mitogen activated protein kinase ( MAPK ) activates Eya by phosphorylating it on two consensus target sites, S402 and S407, and that this activation potentiates the ability of Eya to drive eye formation ... We conclude that, in contrast to ectopic eye formation, MAPK mediated phosphorylation of Eya on S402 and S407 does not play a role in normal development