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F2RL1 — RELA

Text-mined interactions from Literome

Bretschneider et al., Br J Pharmacol 1999 : Activation of NFkappaB via either PAR-1 or PAR-2 does not predict mitogenesis
Buddenkotte et al., J Invest Dermatol 2005 (Dermatitis, Atopic) : Electrophoretic mobility shift assays and morphological transduction studies revealed PAR2 induced activation and translocation of nuclear factor kappa B (NF-kappaB) in primary human KTC with a maximum after 1 h. Supershift analysis demonstrated acivation of the p50/p65 heterodimer complex
Fyfe et al., Cytokine 2005 (Inflammation...) : Unlike IL-1beta, PAR-2 stimulation did not activate NF-kappaB , which may explain the lack of IL-8 expression
Syeda et al., J Biol Chem 2006 : Activation of PAR-1 or PAR-2 promoted nuclear translocation and phosphorylation of p65-NF-kappaB, and thrombin induced but not PAR-2 induced p65-NF-kappaB phosphorylation was reduced by inhibition of MEK or p38MAPK
Goon Goh et al., Cell Signal 2008 : Overall these novel data demonstrate an IKK2 dependent, predominantly G-protein independent pathway involved in PAR-2 regulation of NFkappaB phosphorylation in keratinocytes
Rallabhandi et al., J Biol Chem 2008 (Inflammation) : In the absence of TLR4, PAR2 induced NF-kappaB activity was inhibited by dominant negative ( DN ) -TRIF or DN-TRAM constructs, but not by DN-MyD88, findings confirmed using cell-permeable, adapter-specific BB loop blocking peptides ... Co-expression of TLR4/MD-2/CD14 with PAR2 in HEK293T cells led to a synergistic increase in AP-induced NF-kappaB signaling that was MyD88 dependent and required a functional TLR4, despite the fact that AP exhibited no TLR4 agonist activity
Goh et al., Br J Pharmacol 2009 : Pretreatment with K-14585 inhibited PAR(2) mediated p65 NFkappaB phosphorylation and NFkappaB-DNA binding