Gene interactions and pathways from curated databases and text-mining

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FGFR3 — PLD4

Text-mined interactions from Literome

Mamoon et al., J Pharmacol Exp Ther 1999 : Inhibition of protein kinase C with calphostin C or bisindolylmaleimide I had no effect on isoproterenol- or forskolin stimulated PLD activity but inhibited ACh activated PLD activity ... PKA inhibition also eliminated inhibition of ACh stimulated PLD activity by forskolin or isoproterenol ... These results suggest that increasing the concentration of cAMP activates PLD via activation of PKA and that the increased activity of PKA also inhibits cholinergic stimulation of PLD , in part at least by inhibiting the activation of phospholipase C by ACh
Mamoon et al., J Biomed Sci 2004 : Activation of ACh induced PLD was inhibited by the tyrosine kinase inhibitor genistein in a concentration dependent manner