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FOS — FOSL1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Matsuo et al., Nat Genet 2000
:
The osteoclast differentiation factor Rankl ( also known as TRANCE, ODF and OPGL ; refs 8-11 ) induces transcription of
Fosl1 in a
c-Fos dependent manner, thereby establishing a link between Rank signalling and the expression of Ap-1 proteins in osteoclast differentiation
Young et al., Mol Cell Biol 2002
(Cell Transformation, Neoplastic) :
These observations suggest that ERK dependent activation of
Fra-1 is
required for
AP-1 transactivation in JB6 cells
Yang et al., Pigment Cell Res 2004
(Melanoma) :
In w3211, c-Jun, JunD and
Fra-1 were
involved in
AP-1 binding, while in w1205, overall AP-1 binding activity was decreased significantly and supershift binding was detected only with JunD antibodies
Myhrstad et al., Nutr Cancer 2006
(Carcinoma, Hepatocellular...) :
Fra-1 is a member of the activator protein 1 (AP-1) family of transcription factors and, due to the lack of transactivation domain Fra-1, can
suppress activation of
AP-1
Sinitsyna et al., Toxicol Appl Pharmacol 2010
:
Without arsenite treatment, binding of JunB and
Fra1 was readily
detected in nuclear extracts from preconfluent cultures and was not detected a week after confluence, while
c-Fos was detected only after confluence
Yoshioka et al., Proc Natl Acad Sci U S A 1995
:
Furthermore,
Fra-1 repressed
AP-1 activity induced by either TPA or expression of c-Jun and c-Fos
Bergers et al., Mol Cell Biol 1995
(Cell Transformation, Neoplastic) :
Transcriptional
activation of the
fra-1 gene by
AP-1 is mediated by regulatory sequences in the first intron ... Constitutive expression of
c-Fos , FosB, Fra-1, or c-Jun in rat fibroblasts
leads to up-regulation of the immediate-early gene
fra-1 ... Using the posttranslational FosER induction system, we demonstrate that this
AP-1 dependent stimulation of
fra-1 expression is rapid, depends on a functional DNA binding domain of FosER, and is a general phenomenon observed in different cell types ... In vitro mutagenesis and functional analysis of the rat fra-1 gene in stably transfected Rat-1A-FosER fibroblasts indicated that basal and
AP-1 regulated expression of the
fra-1 gene depends on regulatory sequences in the first intron which comprise a consensus AP-1 site and two AP-1-like elements
Parra et al., Mol Cell Biol 1997
:
LFA-3
induced primarily Jun-D,
Fra-1 , and Fra-2, while B7-1 induced
June-D-Fos complexes
Schreiber et al., Oncogene 1997
(Osteosclerosis) :
Absence of
c-Fos leads to significantly reduced serum stimulation of
fra-1 expression in gene targeted mouse fibroblasts, demonstrating that mitogen induction of fra-1 is partially mediated by c-Fos/AP-1 ... Absence of c-Fos leads to significantly reduced serum stimulation of fra-1 expression in gene targeted mouse fibroblasts, demonstrating that mitogen induction of
fra-1 is partially
mediated by
c-Fos/AP-1
Casamassimi et al., Cancer Res 1998
:
Fra-1 and c-jun were
induced by p53, resulting in increased
AP-1 levels
Kustikova et al., Mol Cell Biol 1998
(Adenocarcinoma...) :
We found that the enhanced level of
AP-1 in CSML100 cells was
due to high expression of
Fra-1 and Fra-2 proteins, which were undetectable in CSML0 nuclear extracts
Cook et al., Mol Cell Biol 1999
:
c-Fos , c-Jun, and JunB are
induced rapidly in response to LPA stimulation, whereas
Fra-1 and Fra-2 are induced after a significant lag ... In cells expressing a conditionally active form of Raf-1 ( DeltaRaf-1 : ER ), we observed that selective, sustained activation of Raf-MEK-MAPK was sufficient to induce expression of
Fra-1 , Fra-2, and JunB but, interestingly,
induced little or no
c-Fos or c-Jun