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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

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FOXO3 — MTOR

Text-mined interactions from Literome

Calay et al., J Invest Dermatol 2010 (Precancerous Conditions) : Diminished Akt activity resulted in deactivation of mammalian target of rapamycin , activation of FoxO3a , and increased sensitivity to apoptosis stimuli
White et al., Mol Cell Endocrinol 2013 : Akt signaling can control skeletal muscle mass through mTOR regulation of protein synthesis and FoxO regulation of protein degradation, and this pathway has been previously identified as a target of androgen signaling
Chen et al., Dev Cell 2010 : Thus, under stress conditions, FoxO inhibits the anabolic activity of mTORC1 , a major consumer of cellular energy, while activating Akt, which increases cellular energy metabolism, thereby maintaining cellular energy homeostasis
Melnik et al., Exp Dermatol 2013 : This hypothesis postulates that antiacne agents either enhance nuclear FoxO activity or inhibit mTORC1