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GAST — MAPK8
Text-mined interactions from Literome
Dehez et al., FEBS Lett 2001
:
We present evidence that
gastrin , binding to a G protein coupled receptor,
activates the p38-mitogen activated protein kinase (
MAPK ) pathway
Schmitz et al., Eur J Clin Invest 2001
(Colorectal Neoplasms) :
Mutation 287V -- > F is associated with a loss of
gastrin induced
MAPK p44/p42 signalling in Colo 320 cells while clonal expansion from single cells is increased by 53.1 +/- 15.9 % when compared to Colo 320 cells expressing wild-type CCK-B/gastrin receptors
Tucker et al., Helicobacter 2010
(Disease Models, Animal...) :
Activation of
gastrin through
MAPK signaling did not require CagA or VacA virulence factors
Todisco et al., J Biol Chem 1995
:
In similar fashion,
gastrin stimulated the activity of
mitogen activated protein kinase , an enzyme known to mediate the induction of the c-fos serum response element in response to growth factor stimulation
Seva et al., Biochem Biophys Res Commun 1997
(Pancreatic Neoplasms) :
In addition, blocking PI-3-kinase activity by wortmannin partially decreased
gastrin induced
MAPK activation ( 42 % +/- 3 ) as well as the tyrosine phosphorylation of She ( 50 % +/- 6 ), an upstream regulator of the Ras dependent MAPK pathway ... These results indicate that at least two signaling pathways lead to
MAPK activation by
gastrin , only one of which is sensitive to PI-3-kinase inhibitors