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GNRH1 — PLD6
Text-mined interactions from Literome
Chamson-Reig et al., Endocrinology 2003
(Luteoma...) :
In the present work, alternate
GnRH induced second messengers such as phospholipase A ( 2 ) and
phospholipase D activation, cAMP production, ERK1/2 phosphorylation, and the presence of G proteins were evaluated to determine GnRH mechanism of action in tumor cells
Netiv et al., FEBS Lett 1991
:
Activation of
phospholipase D by
GnRH-A was dose- and time dependent and was blocked by a GnRH receptor antagonist [ D-pClPhe2,D-Trp3.6 ] GnRH ...
GnRH-A stimulated
phospholipase D activity after a lag of 1-2 min
Naor et al., Front Neuroendocrinol 2009
(Calcium Signaling...) :
The interaction of
GnRH with its cognate type I receptor ( GnRHR ) in pituitary gonadotropes
results in the activation of Gq/G ( 11 ), phospholipase Cbeta ( PLCbetaI ), PLA(2), and
PLD
Liscovitch et al., J Biol Chem 1989
:
We have investigated the
stimulation of
phospholipase D activity by the gonadotropin releasing hormone receptor agonist [ D-Ala6, des-Gly10 ]
GnRH N-ethylamide (GnRH-A) in preovulatory, cultured granulosa cells
Cesnjaj et al., Mol Biol Cell 1995
:
Also,
phospholipase D activity, estimated by the production of phosphatidylethanol from phosphatidylcholine in the presence of ethanol, was
stimulated by
GnRH but not ET-1 ... Such formation of phosphatidylethanol at the expense of phosphatidic acid ( PA ) during
GnRH induced activation of
phospholipase D significantly reduced the production of PA, DG, and cytidine diphosphate diacylglycerol
Rao et al., Endocrinology 1997
:
No significant changes in
GnRH induced
phospholipase D activity and diacylglycerol production were observed in wortmannin treated pituitary cells during the sustained phase of agonist stimulation
Poulin et al., Mol Cell Endocrinol 1998
:
We studied in a gonadotrope cell line ( alphaT3-1 ) the effects of short as well as long term GnRH pretreatments on the
GnRH induced phospholipases-C (PLC), -A2 ( PLA2 ) and -D (
PLD ) activities, by measuring the production of IP3, total inositol phosphates ( IPs ), arachidonic acid ( AA ) and phosphatidylethanol ( PEt ) respectively