White et al., Mol Endocrinol 1999
:
We suggest that GnRH regulation of the GnRHR gene is partially mediated by an ERK dependent activation of a canonical AP-1 site located in the proximal promoter of the GnRHR gene
Shah et al., J Biol Chem 2003
:
Neither EGF nor GnRH receptor activation caused translocation of phospho-ERK1/2 into the nucleus in GT1-7 cells
Kraus et al., J Biol Chem 2003
:
ERK activation by GnRHR is mediated by the EGF receptor, which activates Ras either directly or via c-Src
White et al., Mol Endocrinol 2008
(MAP Kinase Signaling System) :
We therefore provide direct evidence, in multiple cellular backgrounds, that coupling of the GnRH receptor to Galpha ( q/11 ), but not to Galpha ( i/o ) or Galpha ( s ), and consequent activation of ERK plays a crucial role in GnRH mediated cell death